FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000872098> ?p ?o ?g. }

• W2000872098 endingPage "707" @default.
• W2000872098 startingPage "703" @default.
• W2000872098 abstract "Therapeutic angiogenesis represents a new paradigm for treatment of ischemic vascular syndromes. However, vascular endothelial growth factor (VEGF) enhances the rate and degree of plaque formation. This study evaluates the potential to block these effects nonspecifically with paclitaxel or specifically with angiostatin.Recombinant human VEGF(165) (rhVEGF) was administrated intramuscularly (2-microg/kg single injection) in combination with adventitial delivery of paclitaxel, angiostatin, or vehicle alone at the site of femoral arterial balloon overdilation injury in New Zealand White rabbits (n = 5 per treatment). Five additional animals with no rhVEGF and no adventitial delivery served as procedural controls. All rabbits were fed according to a 0.25% cholesterol diet beginning 28 days before angioplasty. Treated arteries were harvested after 7 days and evaluated to determine intima-to-media (I/M) ratios, macrophage infiltrate, and endothelial cell density.On histologic analysis, the rhVEGF/gel control group exhibited a mean I/M ratio of 0.337 +/- 0.028, a 77% increase over procedural controls, which exhibited a mean I/M of 0.190 +/- 0.010. rhVEGF/paclitaxel reduced I/M ratios to 0.151 +/- 0.007. In contrast, specific antiangiogenic therapy (rhVEGF/angiostatin) reduced I/M ratios to 0.032 +/- 0.003, a 91% decrease relative to rhVEGF/gel and an 83% decrease relative to procedural controls (P =.001 for each comparison). Local macrophages and endothelial cells also decreased with treatment.This study shows that paclitaxel and angiostatin each afford local protection against rhVEGF-mediated increases in neointima. Angiostatin further prevents progression of underlying neointima. These local therapies may allow broader use of therapeutic angiogenesis while avoiding and treating potentially undesirable effects." @default.
• W2000872098 created "2016-06-24" @default.
• W2000872098 creator A5012702984 @default.
• W2000872098 creator A5019505258 @default.
• W2000872098 creator A5037533038 @default.
• W2000872098 creator A5066861587 @default.
• W2000872098 creator A5066932092 @default.
• W2000872098 creator A5073025604 @default.
• W2000872098 date "2002-07-01" @default.
• W2000872098 modified "2023-10-13" @default.
• W2000872098 title "Inhibition of Vascular Endothelial Growth Factor–mediated Neointima Progression with Angiostatin or Paclitaxel" @default.
• W2000872098 cites W1480509123 @default.
• W2000872098 cites W1561059299 @default.
• W2000872098 cites W1974790290 @default.
• W2000872098 cites W1981428626 @default.
• W2000872098 cites W1983763042 @default.
• W2000872098 cites W1999359428 @default.
• W2000872098 cites W2015789556 @default.
• W2000872098 cites W2030602309 @default.
• W2000872098 cites W2032207767 @default.
• W2000872098 cites W2043297474 @default.
• W2000872098 cites W2043863730 @default.
• W2000872098 cites W2053704719 @default.
• W2000872098 cites W2057106552 @default.
• W2000872098 cites W2066407369 @default.
• W2000872098 cites W2067980906 @default.
• W2000872098 cites W2075333521 @default.
• W2000872098 cites W2090492904 @default.
• W2000872098 cites W2098444281 @default.
• W2000872098 cites W2108145145 @default.
• W2000872098 cites W2117661440 @default.
• W2000872098 cites W2120582139 @default.
• W2000872098 cites W2131798870 @default.
• W2000872098 cites W2137570167 @default.
• W2000872098 cites W2152639592 @default.
• W2000872098 cites W4241959557 @default.
• W2000872098 doi "https://doi.org/10.1016/s1051-0443(07)61847-8" @default.
• W2000872098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12119329" @default.
• W2000872098 hasPublicationYear "2002" @default.
• W2000872098 type Work @default.
• W2000872098 sameAs 2000872098 @default.
• W2000872098 citedByCount "34" @default.
• W2000872098 countsByYear W20008720982014 @default.
• W2000872098 countsByYear W20008720982016 @default.
• W2000872098 crossrefType "journal-article" @default.
• W2000872098 hasAuthorship W2000872098A5012702984 @default.
• W2000872098 hasAuthorship W2000872098A5019505258 @default.
• W2000872098 hasAuthorship W2000872098A5037533038 @default.
• W2000872098 hasAuthorship W2000872098A5066861587 @default.
• W2000872098 hasAuthorship W2000872098A5066932092 @default.
• W2000872098 hasAuthorship W2000872098A5073025604 @default.
• W2000872098 hasConcept C106812560 @default.
• W2000872098 hasConcept C126322002 @default.
• W2000872098 hasConcept C142724271 @default.
• W2000872098 hasConcept C167734588 @default.
• W2000872098 hasConcept C2776694085 @default.
• W2000872098 hasConcept C2776992346 @default.
• W2000872098 hasConcept C2777025900 @default.
• W2000872098 hasConcept C2777292972 @default.
• W2000872098 hasConcept C2777339539 @default.
• W2000872098 hasConcept C2778283817 @default.
• W2000872098 hasConcept C2778583881 @default.
• W2000872098 hasConcept C2780326628 @default.
• W2000872098 hasConcept C2780394083 @default.
• W2000872098 hasConcept C71924100 @default.
• W2000872098 hasConcept C98274493 @default.
• W2000872098 hasConceptScore W2000872098C106812560 @default.
• W2000872098 hasConceptScore W2000872098C126322002 @default.
• W2000872098 hasConceptScore W2000872098C142724271 @default.
• W2000872098 hasConceptScore W2000872098C167734588 @default.
• W2000872098 hasConceptScore W2000872098C2776694085 @default.
• W2000872098 hasConceptScore W2000872098C2776992346 @default.
• W2000872098 hasConceptScore W2000872098C2777025900 @default.
• W2000872098 hasConceptScore W2000872098C2777292972 @default.
• W2000872098 hasConceptScore W2000872098C2777339539 @default.
• W2000872098 hasConceptScore W2000872098C2778283817 @default.
• W2000872098 hasConceptScore W2000872098C2778583881 @default.
• W2000872098 hasConceptScore W2000872098C2780326628 @default.
• W2000872098 hasConceptScore W2000872098C2780394083 @default.
• W2000872098 hasConceptScore W2000872098C71924100 @default.
• W2000872098 hasConceptScore W2000872098C98274493 @default.
• W2000872098 hasIssue "7" @default.
• W2000872098 hasLocation W20008720981 @default.
• W2000872098 hasLocation W20008720982 @default.
• W2000872098 hasOpenAccess W2000872098 @default.
• W2000872098 hasPrimaryLocation W20008720981 @default.
• W2000872098 hasRelatedWork W2027302122 @default.
• W2000872098 hasRelatedWork W2027539830 @default.
• W2000872098 hasRelatedWork W2036101787 @default.
• W2000872098 hasRelatedWork W2090846657 @default.
• W2000872098 hasRelatedWork W2360933366 @default.
• W2000872098 hasRelatedWork W2389259733 @default.
• W2000872098 hasRelatedWork W2392166704 @default.
• W2000872098 hasRelatedWork W2419267623 @default.
• W2000872098 hasRelatedWork W2531664817 @default.
• W2000872098 hasRelatedWork W335699998 @default.
• W2000872098 hasVolume "13" @default.
• W2000872098 isParatext "false" @default.

• next