FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000872281> ?p ?o ?g. }

• W2000872281 endingPage "111" @default.
• W2000872281 startingPage "104" @default.
• W2000872281 abstract "Syndromes of fear/anxiety are currently ill-defined, with no accepted human biomarkers for anxiety-specific processes. A unique common neural action of different classes of anxiolytic drugs may provide such a biomarker. In rodents, a reduction in low frequency (4–12 Hz; “theta”) brain rhythmicity is produced by all anxiolytics (even those lacking panicolytic or antidepressant action) and not by any non-anxiolytics. This rhythmicity is a key property of the Behavioural Inhibition System (BIS) postulated to be one neural substrate of anxiety. We sought homologous anxiolytic-sensitive changes in human surface EEG rhythmicity. Thirty-four healthy volunteers in parallel groups were administered double blind single doses of triazolam 0.25 mg, buspirone 10 mg or placebo 1 hour prior to completing the stop-signal task. Right frontal conflict-specific EEG power (previously shown to correlate with trait anxiety and neuroticism in this task) was extracted as a contrast between trials with balanced approach–avoidance (stop-go) conflict and the average of trials with net approach and net avoidance. Compared with placebo, both triazolam and buspirone decreased right-frontal, 9–10 Hz, conflict-specific-power. Only one dose of each of only two classes of anxiolytic and no non-anxiolytics were tested, so additional tests are needed to determine generality. There is a distinct rhythmic system in humans that is sensitive to both classical/GABAergic and novel/serotonergic anxiolytics. This conflict-specific rhythmicity should provide a biomarker, with a strong pre-clinical neuropsychology, for a novel approach to classifying anxiety disorders." @default.
• W2000872281 created "2016-06-24" @default.
• W2000872281 creator A5010069066 @default.
• W2000872281 creator A5020888113 @default.
• W2000872281 creator A5022110262 @default.
• W2000872281 creator A5064113214 @default.
• W2000872281 creator A5090086572 @default.
• W2000872281 date "2013-05-01" @default.
• W2000872281 modified "2023-09-26" @default.
• W2000872281 title "Anti-anxiety drugs reduce conflict-specific “theta”—A possible human anxiety-specific biomarker" @default.
• W2000872281 cites W1551608302 @default.
• W2000872281 cites W1967711862 @default.
• W2000872281 cites W1973676211 @default.
• W2000872281 cites W2000709742 @default.
• W2000872281 cites W2008792759 @default.
• W2000872281 cites W2012297440 @default.
• W2000872281 cites W2016492613 @default.
• W2000872281 cites W2017062859 @default.
• W2000872281 cites W2024576889 @default.
• W2000872281 cites W2029701168 @default.
• W2000872281 cites W2030373537 @default.
• W2000872281 cites W2032809789 @default.
• W2000872281 cites W2038016568 @default.
• W2000872281 cites W2039729702 @default.
• W2000872281 cites W2043305968 @default.
• W2000872281 cites W2052902755 @default.
• W2000872281 cites W2053098418 @default.
• W2000872281 cites W2057561126 @default.
• W2000872281 cites W2061955553 @default.
• W2000872281 cites W2071492556 @default.
• W2000872281 cites W2072646528 @default.
• W2000872281 cites W2079987287 @default.
• W2000872281 cites W2082212379 @default.
• W2000872281 cites W2089030269 @default.
• W2000872281 cites W2093427998 @default.
• W2000872281 cites W2116200167 @default.
• W2000872281 cites W2117151134 @default.
• W2000872281 cites W2119314959 @default.
• W2000872281 cites W2122660499 @default.
• W2000872281 cites W2124833043 @default.
• W2000872281 cites W2139622563 @default.
• W2000872281 cites W2142459046 @default.
• W2000872281 cites W2145736646 @default.
• W2000872281 cites W2159417725 @default.
• W2000872281 doi "https://doi.org/10.1016/j.jad.2012.11.057" @default.
• W2000872281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23261140" @default.
• W2000872281 hasPublicationYear "2013" @default.
• W2000872281 type Work @default.
• W2000872281 sameAs 2000872281 @default.
• W2000872281 citedByCount "45" @default.
• W2000872281 countsByYear W20008722812013 @default.
• W2000872281 countsByYear W20008722812014 @default.
• W2000872281 countsByYear W20008722812015 @default.
• W2000872281 countsByYear W20008722812016 @default.
• W2000872281 countsByYear W20008722812017 @default.
• W2000872281 countsByYear W20008722812018 @default.
• W2000872281 countsByYear W20008722812019 @default.
• W2000872281 countsByYear W20008722812020 @default.
• W2000872281 countsByYear W20008722812021 @default.
• W2000872281 countsByYear W20008722812022 @default.
• W2000872281 countsByYear W20008722812023 @default.
• W2000872281 crossrefType "journal-article" @default.
• W2000872281 hasAuthorship W2000872281A5010069066 @default.
• W2000872281 hasAuthorship W2000872281A5020888113 @default.
• W2000872281 hasAuthorship W2000872281A5022110262 @default.
• W2000872281 hasAuthorship W2000872281A5064113214 @default.
• W2000872281 hasAuthorship W2000872281A5090086572 @default.
• W2000872281 hasConcept C118552586 @default.
• W2000872281 hasConcept C126322002 @default.
• W2000872281 hasConcept C15744967 @default.
• W2000872281 hasConcept C169760540 @default.
• W2000872281 hasConcept C170493617 @default.
• W2000872281 hasConcept C185592680 @default.
• W2000872281 hasConcept C2775864247 @default.
• W2000872281 hasConcept C2777196872 @default.
• W2000872281 hasConcept C2777287423 @default.
• W2000872281 hasConcept C2777765862 @default.
• W2000872281 hasConcept C2778173252 @default.
• W2000872281 hasConcept C2781197716 @default.
• W2000872281 hasConcept C2909738485 @default.
• W2000872281 hasConcept C55493867 @default.
• W2000872281 hasConcept C558461103 @default.
• W2000872281 hasConcept C71924100 @default.
• W2000872281 hasConceptScore W2000872281C118552586 @default.
• W2000872281 hasConceptScore W2000872281C126322002 @default.
• W2000872281 hasConceptScore W2000872281C15744967 @default.
• W2000872281 hasConceptScore W2000872281C169760540 @default.
• W2000872281 hasConceptScore W2000872281C170493617 @default.
• W2000872281 hasConceptScore W2000872281C185592680 @default.
• W2000872281 hasConceptScore W2000872281C2775864247 @default.
• W2000872281 hasConceptScore W2000872281C2777196872 @default.
• W2000872281 hasConceptScore W2000872281C2777287423 @default.
• W2000872281 hasConceptScore W2000872281C2777765862 @default.
• W2000872281 hasConceptScore W2000872281C2778173252 @default.
• W2000872281 hasConceptScore W2000872281C2781197716 @default.
• W2000872281 hasConceptScore W2000872281C2909738485 @default.
• W2000872281 hasConceptScore W2000872281C55493867 @default.
• W2000872281 hasConceptScore W2000872281C558461103 @default.

• next