Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000873516> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2000873516 endingPage "21" @default.
- W2000873516 startingPage "15" @default.
- W2000873516 abstract "The perception of bronchoconstriction may be modulated by airway inflammation. However, the effect of inhaled corticosteroid (ICS) treatment on perception in subjects with asthma has received limited study. The aim of this study was to determine the effect of inhaled budesonide on the perception of breathlessness induced by histamine challenge. Thirty-five subjects with poorly controlled asthma were randomized to receive budesonide (1,600 or 3,200 microg/d) for 8 wk, followed by 8 wk at 1,600 microg/d and subsequent downtitration according to a clinical algorithm. Borg scores were recorded during histamine challenges performed at baseline and at 8, 16, 24, 48, and 72 wk. Perception was estimated as the slope of Borg/% fall FEV(1). The Borg/FEV(1) slope increased significantly after 8 wk of budesonide (0.09 [0.08-0.12] to 0.15 [0.11-0.19], p = 0.002), and remained increased compared with baseline values at all subsequent visits. There were no significant differences in Borg/ FEV(1) slope between subjects who were and were not taking ICS at study entry. The magnitude of change in the Borg/FEV(1) slope did not differ significantly between treatment groups and was not related to changes in baseline FEV(1), airway hyperresponsiveness, blood eosinophils, or serum eosinophil cationic protein (ECP). We conclude that treatment with budesonide enhances the perception of airway narrowing, but the effect is unrelated to budesonide dose, or to changes in circulating eosinophil markers." @default.
- W2000873516 created "2016-06-24" @default.
- W2000873516 creator A5011926591 @default.
- W2000873516 creator A5039913549 @default.
- W2000873516 creator A5045970183 @default.
- W2000873516 creator A5047181213 @default.
- W2000873516 creator A5068265981 @default.
- W2000873516 creator A5071426070 @default.
- W2000873516 creator A5090708142 @default.
- W2000873516 date "2002-01-01" @default.
- W2000873516 modified "2023-10-13" @default.
- W2000873516 title "Effect of Budesonide on the Perception of Induced Airway Narrowing in Subjects with Asthma" @default.
- W2000873516 cites W1965530277 @default.
- W2000873516 cites W1966802323 @default.
- W2000873516 cites W1976946946 @default.
- W2000873516 cites W2002122646 @default.
- W2000873516 cites W2004441096 @default.
- W2000873516 cites W2013957246 @default.
- W2000873516 cites W2016509364 @default.
- W2000873516 cites W2032557137 @default.
- W2000873516 cites W2053578943 @default.
- W2000873516 cites W2055260869 @default.
- W2000873516 cites W2081063103 @default.
- W2000873516 cites W2081920706 @default.
- W2000873516 cites W2091883370 @default.
- W2000873516 cites W2102103749 @default.
- W2000873516 cites W2106245415 @default.
- W2000873516 cites W2108299940 @default.
- W2000873516 cites W2112355851 @default.
- W2000873516 cites W2123247260 @default.
- W2000873516 cites W2135407961 @default.
- W2000873516 cites W2143554334 @default.
- W2000873516 cites W2234966368 @default.
- W2000873516 cites W2401572099 @default.
- W2000873516 cites W2417016827 @default.
- W2000873516 cites W28991458 @default.
- W2000873516 doi "https://doi.org/10.1164/ajrccm.165.1.2106130" @default.
- W2000873516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11779724" @default.
- W2000873516 hasPublicationYear "2002" @default.
- W2000873516 type Work @default.
- W2000873516 sameAs 2000873516 @default.
- W2000873516 citedByCount "47" @default.
- W2000873516 countsByYear W20008735162012 @default.
- W2000873516 countsByYear W20008735162013 @default.
- W2000873516 countsByYear W20008735162014 @default.
- W2000873516 countsByYear W20008735162019 @default.
- W2000873516 countsByYear W20008735162021 @default.
- W2000873516 crossrefType "journal-article" @default.
- W2000873516 hasAuthorship W2000873516A5011926591 @default.
- W2000873516 hasAuthorship W2000873516A5039913549 @default.
- W2000873516 hasAuthorship W2000873516A5045970183 @default.
- W2000873516 hasAuthorship W2000873516A5047181213 @default.
- W2000873516 hasAuthorship W2000873516A5068265981 @default.
- W2000873516 hasAuthorship W2000873516A5071426070 @default.
- W2000873516 hasAuthorship W2000873516A5090708142 @default.
- W2000873516 hasConcept C105922876 @default.
- W2000873516 hasConcept C126322002 @default.
- W2000873516 hasConcept C2776042228 @default.
- W2000873516 hasConcept C2776136866 @default.
- W2000873516 hasConcept C2776804153 @default.
- W2000873516 hasConcept C2777037409 @default.
- W2000873516 hasConcept C2780769369 @default.
- W2000873516 hasConcept C42219234 @default.
- W2000873516 hasConcept C71924100 @default.
- W2000873516 hasConcept C88675164 @default.
- W2000873516 hasConceptScore W2000873516C105922876 @default.
- W2000873516 hasConceptScore W2000873516C126322002 @default.
- W2000873516 hasConceptScore W2000873516C2776042228 @default.
- W2000873516 hasConceptScore W2000873516C2776136866 @default.
- W2000873516 hasConceptScore W2000873516C2776804153 @default.
- W2000873516 hasConceptScore W2000873516C2777037409 @default.
- W2000873516 hasConceptScore W2000873516C2780769369 @default.
- W2000873516 hasConceptScore W2000873516C42219234 @default.
- W2000873516 hasConceptScore W2000873516C71924100 @default.
- W2000873516 hasConceptScore W2000873516C88675164 @default.
- W2000873516 hasIssue "1" @default.
- W2000873516 hasLocation W20008735161 @default.
- W2000873516 hasLocation W20008735162 @default.
- W2000873516 hasOpenAccess W2000873516 @default.
- W2000873516 hasPrimaryLocation W20008735161 @default.
- W2000873516 hasRelatedWork W1795103282 @default.
- W2000873516 hasRelatedWork W2003234817 @default.
- W2000873516 hasRelatedWork W2009564877 @default.
- W2000873516 hasRelatedWork W2051836505 @default.
- W2000873516 hasRelatedWork W2083303897 @default.
- W2000873516 hasRelatedWork W2099781248 @default.
- W2000873516 hasRelatedWork W2123928308 @default.
- W2000873516 hasRelatedWork W2411935288 @default.
- W2000873516 hasRelatedWork W2421330260 @default.
- W2000873516 hasRelatedWork W2463786592 @default.
- W2000873516 hasVolume "165" @default.
- W2000873516 isParatext "false" @default.
- W2000873516 isRetracted "false" @default.
- W2000873516 magId "2000873516" @default.
- W2000873516 workType "article" @default.