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- W2000873619 abstract "The characteristic feature in PFC is pulmonary vasospasm leading to hypoxia in the absence of radiological evidence on parenchymal lung disease. According to Riggs right ventricular pre-ejection period/right ventricular ejection time ratio (RPEP/RVET) correlates to pulmonary diastolic pressure (Pediatrics 59 (1977)338) .Ten newborn having PFC were studied by echocardiography and phospholipid analysis of lung effluent. Mechanical ventilation was started if hypoxia and metabolic acidosis persisted despite O2 and NaHCO3(fr 30(27-32)/min,Tinsp 1 sec,PEEP 4(3-5)cmH2O,Pinsp 25(21-32)cmH2O). After changing the frequency to 60(54-64)/min and Tinsp to 0.6-0.7 sec., the arterial pO2 increased by 52(30-110)mmHg within 15 min (N=5). Meanwhile RPEP/RVET decreased from 0.64 to 0.46 (N=2). During 4 days RPEP/RVET fell from 0.62(.43-.84) (age 0.3-1.2d)to 0. 37 (.30-.48)paralleling the clinical course. One infant died. Among phospholipids isolated from endotracheal suctions phosphatidylglycerol (PG) was absent in eight cases, and present in two (one meconium aspiration, one pulmonary haemorrhage) .PG always appeared during the recovery. Deficient surfactant indicates the importance of microatelectasis in PFC. High frequency ventilation with long Tinsp seems to be an effective and safe treatment." @default.
- W2000873619 created "2016-06-24" @default.
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- W2000873619 date "1979-01-01" @default.
- W2000873619 modified "2023-09-27" @default.
- W2000873619 title "Efficient ventilation relieves pulmonary vasospasm in persistent fetal circulation (PFC). Evidence on surfactant deficiency" @default.
- W2000873619 doi "https://doi.org/10.1203/00006450-197901000-00044" @default.
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