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- W2000873818 abstract "Inflammation has been implicated in the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative diseases. We have examined the potential role of some chemokine/chemokine receptors in this process. It is known that CXCR2 is a strongly expressed chemokine receptor on neurons and is strongly upregulated in AD in a subpopulation of neuritic plaques. Here, we show that one of the CXCR2 ligand GROalpha/KC can be a potent trigger for the ERK1/2 and PI-3 kinase pathways, as well as tau hyperphosphorylation in the mouse primary cortical neurons. GROalpha immunoreactivity can be detected in a subpopulation of neurons in normal and AD. Therefore, the CXCR2-ligand pair may have a potent pathophysiological role in neurodegenerative diseases." @default.
- W2000873818 created "2016-06-24" @default.
- W2000873818 creator A5048484185 @default.
- W2000873818 creator A5068688487 @default.
- W2000873818 date "2002-01-01" @default.
- W2000873818 modified "2023-10-06" @default.
- W2000873818 title "GROα/KC, a chemokine receptor CXCR2 ligand, can be a potent trigger for neuronal ERK1/2 and PI-3 kinase pathways and for tau hyperphosphorylation—a role in Alzheimer's disease?" @default.
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- W2000873818 doi "https://doi.org/10.1016/s0165-5728(01)00463-5" @default.
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