Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000874344> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2000874344 endingPage "235" @default.
- W2000874344 startingPage "229" @default.
- W2000874344 abstract "In one well-equilibrated parkinsonian patient treated with combined L-dopa and carbidopa (Sinemet), we have observed changes in treatment efficacy while receiving spiramycin (Rovamycine) for an intercurrent respiratory infection. A preliminary study of the pharmacokinetics of L-dopa and its main metabolites 3-O-methyldopa (3-OMD) and dihydroxyphenylacetic acid (dopac) in two parkinsonian patients treated with Sinemet has revealed a marked decrease in the AUC0–360 of these two metabolites after a 3-day course of Rovamycine. In order to confirm this interaction, we have studied the modifications of the pharmacokinetics of L-dopa, 3-OMD, dopac, and carbidopa in eight male healthy volunteers after a single dose of Sinemet 250 (L-dopa, 250 mg and carbidopa, 25 mg) before and after a 3-day course of Rovamycine. Our study confirms this interaction. After spiramycin, we observed a marked reduction in AUC0–360 for L-dopa (p < 0.001), 3-OMD (p < 0.001), and carbidopa (p < 0.001), and an increase in AUC0–360 for dopac (p < 0.01). The L-dopa elimination half-life was increased (p < 0.012); differences in peak plasma concentrations did not attain statistical significance. We think that these modifications in L-dopa pharmacokinetics after spiramycin are due to nonabsorption of carbidopa secondary to modified gastrointestinal motility." @default.
- W2000874344 created "2016-06-24" @default.
- W2000874344 creator A5009584580 @default.
- W2000874344 creator A5016399305 @default.
- W2000874344 creator A5047277282 @default.
- W2000874344 creator A5049012003 @default.
- W2000874344 creator A5069946536 @default.
- W2000874344 creator A5083199069 @default.
- W2000874344 date "1992-06-01" @default.
- W2000874344 modified "2023-09-27" @default.
- W2000874344 title "Effect of a Macrolide (Spiramycin) on the Pharmacokinetics of L-dopa and Carbidopa in Healthy Volunteers" @default.
- W2000874344 doi "https://doi.org/10.1097/00002826-199206000-00003" @default.
- W2000874344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1394243" @default.
- W2000874344 hasPublicationYear "1992" @default.
- W2000874344 type Work @default.
- W2000874344 sameAs 2000874344 @default.
- W2000874344 citedByCount "14" @default.
- W2000874344 countsByYear W20008743442015 @default.
- W2000874344 countsByYear W20008743442017 @default.
- W2000874344 countsByYear W20008743442020 @default.
- W2000874344 crossrefType "journal-article" @default.
- W2000874344 hasAuthorship W2000874344A5009584580 @default.
- W2000874344 hasAuthorship W2000874344A5016399305 @default.
- W2000874344 hasAuthorship W2000874344A5047277282 @default.
- W2000874344 hasAuthorship W2000874344A5049012003 @default.
- W2000874344 hasAuthorship W2000874344A5069946536 @default.
- W2000874344 hasAuthorship W2000874344A5083199069 @default.
- W2000874344 hasConcept C112705442 @default.
- W2000874344 hasConcept C126322002 @default.
- W2000874344 hasConcept C185592680 @default.
- W2000874344 hasConcept C2776754145 @default.
- W2000874344 hasConcept C2779134260 @default.
- W2000874344 hasConcept C2779172262 @default.
- W2000874344 hasConcept C2779734285 @default.
- W2000874344 hasConcept C2780206985 @default.
- W2000874344 hasConcept C2780304432 @default.
- W2000874344 hasConcept C501593827 @default.
- W2000874344 hasConcept C55493867 @default.
- W2000874344 hasConcept C71924100 @default.
- W2000874344 hasConcept C98274493 @default.
- W2000874344 hasConceptScore W2000874344C112705442 @default.
- W2000874344 hasConceptScore W2000874344C126322002 @default.
- W2000874344 hasConceptScore W2000874344C185592680 @default.
- W2000874344 hasConceptScore W2000874344C2776754145 @default.
- W2000874344 hasConceptScore W2000874344C2779134260 @default.
- W2000874344 hasConceptScore W2000874344C2779172262 @default.
- W2000874344 hasConceptScore W2000874344C2779734285 @default.
- W2000874344 hasConceptScore W2000874344C2780206985 @default.
- W2000874344 hasConceptScore W2000874344C2780304432 @default.
- W2000874344 hasConceptScore W2000874344C501593827 @default.
- W2000874344 hasConceptScore W2000874344C55493867 @default.
- W2000874344 hasConceptScore W2000874344C71924100 @default.
- W2000874344 hasConceptScore W2000874344C98274493 @default.
- W2000874344 hasIssue "3" @default.
- W2000874344 hasLocation W20008743441 @default.
- W2000874344 hasLocation W20008743442 @default.
- W2000874344 hasOpenAccess W2000874344 @default.
- W2000874344 hasPrimaryLocation W20008743441 @default.
- W2000874344 hasRelatedWork W1541951154 @default.
- W2000874344 hasRelatedWork W2000874344 @default.
- W2000874344 hasRelatedWork W2017820642 @default.
- W2000874344 hasRelatedWork W2040080010 @default.
- W2000874344 hasRelatedWork W2339308015 @default.
- W2000874344 hasRelatedWork W2415432476 @default.
- W2000874344 hasRelatedWork W2533484740 @default.
- W2000874344 hasRelatedWork W2748952813 @default.
- W2000874344 hasRelatedWork W2899084033 @default.
- W2000874344 hasRelatedWork W3203787889 @default.
- W2000874344 hasVolume "15" @default.
- W2000874344 isParatext "false" @default.
- W2000874344 isRetracted "false" @default.
- W2000874344 magId "2000874344" @default.
- W2000874344 workType "article" @default.