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- W2000875122 abstract "Abstract We studied proliferative activity in the breast tissue from 40 healthy premenopausal women who underwent reduction mammoplasty. Twenty-four women had regular menstrual cycles; 16 were taking combined oral contraceptives. Lobuloalveolar tissue was examined by means of the Ki-67/MIB 1 antibody to identify proliferating cells. The number of positive-staining cells was related to the estimated number of cells to form an activity ratio (AR). We found a significantly higher AR in the secretory compared with the proliferative phase of the menstrual cycle, and a tendency for higher AR values in late compared with early oral contraceptive treatment cycles. In multivariate analyses, the secretory phase was associated with a significantly higher AR, and oral contraceptive use was associated with a higher AR than natural cycles. Our data suggest that progesterone/progestins augment proliferation in the normal breast epithelium and highlight the complexity of cell regulatory factors affected by exogenous steroids." @default.
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- W2000875122 date "1998-06-01" @default.
- W2000875122 modified "2023-10-16" @default.
- W2000875122 title "Epithelial proliferation in the normal human breast in relation to endogenous hormones and oral contraceptive use" @default.
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- W2000875122 doi "https://doi.org/10.1016/s0960-9776(98)90029-7" @default.
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