Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000875208> ?p ?o ?g. }
- W2000875208 endingPage "1839" @default.
- W2000875208 startingPage "1830" @default.
- W2000875208 abstract "Discovery of Bruton's tyrosine kinase (BTK) mutations as the cause for X-linked agammaglobulinemia was a milestone in understanding the genetic basis of primary immunodeficiencies. Since then, studies have highlighted the critical role of this enzyme in B-cell development and function, and particularly in B-cell receptor signaling. Because its deletion affects mostly B cells, BTK has become an attractive therapeutic target in autoimmune disorders and B-cell malignancies. Ibrutinib (PCI-32765) is the most advanced BTK inhibitor in clinical testing, with ongoing phase III clinical trials in patients with chronic lymphocytic leukemia and mantle-cell lymphoma. In this article, we discuss key discoveries related to BTK and clinically relevant aspects of BTK inhibitors, and we provide an outlook into clinical development and open questions regarding BTK inhibitor therapy." @default.
- W2000875208 created "2016-06-24" @default.
- W2000875208 creator A5034625499 @default.
- W2000875208 creator A5058755419 @default.
- W2000875208 date "2014-06-10" @default.
- W2000875208 modified "2023-10-17" @default.
- W2000875208 title "Bruton's Tyrosine Kinase: From X-Linked Agammaglobulinemia Toward Targeted Therapy for B-Cell Malignancies" @default.
- W2000875208 cites W1506889194 @default.
- W2000875208 cites W1523413388 @default.
- W2000875208 cites W1528508275 @default.
- W2000875208 cites W159153534 @default.
- W2000875208 cites W1618672876 @default.
- W2000875208 cites W1759857471 @default.
- W2000875208 cites W1810839417 @default.
- W2000875208 cites W1826755587 @default.
- W2000875208 cites W1945997263 @default.
- W2000875208 cites W1966408108 @default.
- W2000875208 cites W1967796318 @default.
- W2000875208 cites W1967835933 @default.
- W2000875208 cites W1970400561 @default.
- W2000875208 cites W1975225711 @default.
- W2000875208 cites W1979816280 @default.
- W2000875208 cites W1982185661 @default.
- W2000875208 cites W1985089042 @default.
- W2000875208 cites W1985441886 @default.
- W2000875208 cites W1990159135 @default.
- W2000875208 cites W2007417599 @default.
- W2000875208 cites W2011950935 @default.
- W2000875208 cites W2011960630 @default.
- W2000875208 cites W2013217534 @default.
- W2000875208 cites W2013909810 @default.
- W2000875208 cites W2016014103 @default.
- W2000875208 cites W2016287628 @default.
- W2000875208 cites W2016591994 @default.
- W2000875208 cites W2017508812 @default.
- W2000875208 cites W2019216438 @default.
- W2000875208 cites W2019526643 @default.
- W2000875208 cites W2022969158 @default.
- W2000875208 cites W2024015921 @default.
- W2000875208 cites W2024104456 @default.
- W2000875208 cites W2025755006 @default.
- W2000875208 cites W2026266460 @default.
- W2000875208 cites W2030040544 @default.
- W2000875208 cites W2033867789 @default.
- W2000875208 cites W2034013604 @default.
- W2000875208 cites W2034763496 @default.
- W2000875208 cites W2037211574 @default.
- W2000875208 cites W2038533386 @default.
- W2000875208 cites W2042271164 @default.
- W2000875208 cites W2042482956 @default.
- W2000875208 cites W2044066127 @default.
- W2000875208 cites W2046304104 @default.
- W2000875208 cites W2047514473 @default.
- W2000875208 cites W2050221685 @default.
- W2000875208 cites W2051321376 @default.
- W2000875208 cites W2052397619 @default.
- W2000875208 cites W2054526083 @default.
- W2000875208 cites W2062482627 @default.
- W2000875208 cites W2063262989 @default.
- W2000875208 cites W2065338378 @default.
- W2000875208 cites W2066030565 @default.
- W2000875208 cites W2069809502 @default.
- W2000875208 cites W2070373231 @default.
- W2000875208 cites W2070829838 @default.
- W2000875208 cites W2071549499 @default.
- W2000875208 cites W2075875145 @default.
- W2000875208 cites W2076867321 @default.
- W2000875208 cites W2080588958 @default.
- W2000875208 cites W2089103836 @default.
- W2000875208 cites W2089941945 @default.
- W2000875208 cites W2091347081 @default.
- W2000875208 cites W2091664866 @default.
- W2000875208 cites W2093365588 @default.
- W2000875208 cites W2093522627 @default.
- W2000875208 cites W2093577878 @default.
- W2000875208 cites W2095764447 @default.
- W2000875208 cites W2099752901 @default.
- W2000875208 cites W2100034730 @default.
- W2000875208 cites W2103820395 @default.
- W2000875208 cites W2104030929 @default.
- W2000875208 cites W2105441566 @default.
- W2000875208 cites W2106018231 @default.
- W2000875208 cites W2107201797 @default.
- W2000875208 cites W2107773259 @default.
- W2000875208 cites W2107820445 @default.
- W2000875208 cites W2113764179 @default.
- W2000875208 cites W2118028844 @default.
- W2000875208 cites W2122681203 @default.
- W2000875208 cites W2125678285 @default.
- W2000875208 cites W2126916805 @default.
- W2000875208 cites W2132472913 @default.
- W2000875208 cites W2132968206 @default.
- W2000875208 cites W2134645992 @default.
- W2000875208 cites W2134971055 @default.
- W2000875208 cites W2138089505 @default.
- W2000875208 cites W2145654455 @default.
- W2000875208 cites W2152676014 @default.
- W2000875208 cites W2154066874 @default.