FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000876750> ?p ?o ?g. }

• W2000876750 endingPage "1866" @default.
• W2000876750 startingPage "1859" @default.
• W2000876750 abstract "The role of cardiac troponin C (cTnC) as a target protein for the calcium sensitization by levosimendan, pimobendan, MCI-154 and EMD 53998 was evaluated using purified recombinant human cTnC. For determination of calcium- and magnesium-dependent binding of the compounds to cTnC a new type of cTnC-HPLAC column was used. Furthermore, dansylated cTnC was utilized to study the effect of the calcium sensitizing compounds on calcium-induced conformation of cTnC. Only levosimendan showed calcium-dependent and to a lesser extent magnesium-dependent retention in the cTnC column. The findings indicate that levosimendan binds both to the N-terminal and C-terminal domains of cTnC. In agreement with this, only levosimendan shifted the calcium-induced fluorescence curve of dansylated cTnC to the left. In the control experiments Ca50 and KCa2+ were calculated to be 2.73 microM and 4 x 10(5) M-1, respectively. Levosimendan at 3 microM decreased the value of Ca50 to 1.19 microM. In conclusion, it is suggested that the mechanism of calcium sensitizing effect of levosimendan, unlike that of the other calcium sensitizers, is based on calcium-dependent binding to the N-terminal domain of cTnC. This is proposed to amplify the trigger of contraction induced by cTnC in the cardiac muscle." @default.
• W2000876750 created "2016-06-24" @default.
• W2000876750 creator A5009985888 @default.
• W2000876750 creator A5023582033 @default.
• W2000876750 creator A5023648775 @default.
• W2000876750 creator A5032482206 @default.
• W2000876750 creator A5069107425 @default.
• W2000876750 creator A5077768057 @default.
• W2000876750 date "1995-09-01" @default.
• W2000876750 modified "2023-09-27" @default.
• W2000876750 title "Cardiac troponin C as a target protein for a novel calcium sensitizing drug, levosimendan" @default.
• W2000876750 cites W1496902535 @default.
• W2000876750 cites W1538093889 @default.
• W2000876750 cites W1550330933 @default.
• W2000876750 cites W1555694689 @default.
• W2000876750 cites W1556535974 @default.
• W2000876750 cites W1577128492 @default.
• W2000876750 cites W1583960539 @default.
• W2000876750 cites W1927140153 @default.
• W2000876750 cites W1972091161 @default.
• W2000876750 cites W1997594013 @default.
• W2000876750 cites W2014298363 @default.
• W2000876750 cites W2014329906 @default.
• W2000876750 cites W2027298594 @default.
• W2000876750 cites W2032463428 @default.
• W2000876750 cites W2033458299 @default.
• W2000876750 cites W2034224779 @default.
• W2000876750 cites W2035705406 @default.
• W2000876750 cites W2035984481 @default.
• W2000876750 cites W2052552544 @default.
• W2000876750 cites W2080301977 @default.
• W2000876750 cites W2084544831 @default.
• W2000876750 cites W2089649406 @default.
• W2000876750 cites W2093774938 @default.
• W2000876750 cites W2328966774 @default.
• W2000876750 cites W2416845759 @default.
• W2000876750 cites W2737899365 @default.
• W2000876750 doi "https://doi.org/10.1016/0022-2828(95)90009-8" @default.
• W2000876750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8523447" @default.
• W2000876750 hasPublicationYear "1995" @default.
• W2000876750 type Work @default.
• W2000876750 sameAs 2000876750 @default.
• W2000876750 citedByCount "285" @default.
• W2000876750 countsByYear W20008767502012 @default.
• W2000876750 countsByYear W20008767502013 @default.
• W2000876750 countsByYear W20008767502014 @default.
• W2000876750 countsByYear W20008767502015 @default.
• W2000876750 countsByYear W20008767502016 @default.
• W2000876750 countsByYear W20008767502017 @default.
• W2000876750 countsByYear W20008767502018 @default.
• W2000876750 countsByYear W20008767502019 @default.
• W2000876750 countsByYear W20008767502020 @default.
• W2000876750 countsByYear W20008767502021 @default.
• W2000876750 countsByYear W20008767502022 @default.
• W2000876750 countsByYear W20008767502023 @default.
• W2000876750 crossrefType "journal-article" @default.
• W2000876750 hasAuthorship W2000876750A5009985888 @default.
• W2000876750 hasAuthorship W2000876750A5023582033 @default.
• W2000876750 hasAuthorship W2000876750A5023648775 @default.
• W2000876750 hasAuthorship W2000876750A5032482206 @default.
• W2000876750 hasAuthorship W2000876750A5069107425 @default.
• W2000876750 hasAuthorship W2000876750A5077768057 @default.
• W2000876750 hasConcept C115725540 @default.
• W2000876750 hasConcept C12554922 @default.
• W2000876750 hasConcept C126322002 @default.
• W2000876750 hasConcept C133927893 @default.
• W2000876750 hasConcept C178790620 @default.
• W2000876750 hasConcept C185592680 @default.
• W2000876750 hasConcept C2777335384 @default.
• W2000876750 hasConcept C2778198053 @default.
• W2000876750 hasConcept C36036425 @default.
• W2000876750 hasConcept C500558357 @default.
• W2000876750 hasConcept C519063684 @default.
• W2000876750 hasConcept C71924100 @default.
• W2000876750 hasConcept C86803240 @default.
• W2000876750 hasConceptScore W2000876750C115725540 @default.
• W2000876750 hasConceptScore W2000876750C12554922 @default.
• W2000876750 hasConceptScore W2000876750C126322002 @default.
• W2000876750 hasConceptScore W2000876750C133927893 @default.
• W2000876750 hasConceptScore W2000876750C178790620 @default.
• W2000876750 hasConceptScore W2000876750C185592680 @default.
• W2000876750 hasConceptScore W2000876750C2777335384 @default.
• W2000876750 hasConceptScore W2000876750C2778198053 @default.
• W2000876750 hasConceptScore W2000876750C36036425 @default.
• W2000876750 hasConceptScore W2000876750C500558357 @default.
• W2000876750 hasConceptScore W2000876750C519063684 @default.
• W2000876750 hasConceptScore W2000876750C71924100 @default.
• W2000876750 hasConceptScore W2000876750C86803240 @default.
• W2000876750 hasIssue "9" @default.
• W2000876750 hasLocation W20008767501 @default.
• W2000876750 hasLocation W20008767502 @default.
• W2000876750 hasOpenAccess W2000876750 @default.
• W2000876750 hasPrimaryLocation W20008767501 @default.
• W2000876750 hasRelatedWork W1986373711 @default.
• W2000876750 hasRelatedWork W2000876750 @default.
• W2000876750 hasRelatedWork W2044848803 @default.
• W2000876750 hasRelatedWork W2058355538 @default.
• W2000876750 hasRelatedWork W2150878264 @default.

• next