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- W2000877291 abstract "Four new derivatives of 8-piperazine ethyl xanthine were synthesized and their bronchospasmolytic activity and A1-adenosine affinity were studied. Their relaxant action in the tracheal muscle was lower than that of theophylline and that of theophylline derivatives substituted at the 7-position. Only compound 9, where the methyl group in the 1-position of the theophylline was substituted by an isobutyl group, shows a good affinity towards the A1-adenosine receptor." @default.
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- W2000877291 date "1995-01-01" @default.
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- W2000877291 title "Structure-Activity Relationships in a Series of 8-Substituted Xanthines as Bronchodilator and A1-Adenosine Receptor Antagonists" @default.
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- W2000877291 doi "https://doi.org/10.1002/ardp.19953280905" @default.
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