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- W20008773 abstract "ABSTRACT Hybridomas continuously producing antigen-specific suppressor molecules were established by the fusion of an AKR thymoma cell line, BW5147, with keyhole limpet hemocyanin (KLH)-specific enriched suppressor T cells from C57BL/6 mice. They were positive for H-2 k , H-2 b , I-J b , Thy 1.1 and Thy 1.2 but lacked I-J k alloantigens and surface immunoglobulins, and were transplantable to (C57BL/6 × AKR)F 1 and (C57BL/6 × C3H)F 1 mice but not to either parental strains. By assaying the activities of extracts or secreted materials, these hybridomas were divided into three functional groups: 1. with antigen-specific suppressive activity, 2. with antigen-nonspecific suppressive activity, and 3. without detectable suppressive activity. The antigen-specific suppressor molecule derived from group 1 cell lines was invariably adsorbable to immunoadsorbents composed of KLH, anti- H-2 b , and anti- I-J b , but not to those of unrelated antigen, anti-mouse Fab and anti-mouse immunoglobulins. The molecular size of the active factor was found to be between 42,000 and 68,000 daltons. The factor derived from group 1 suppressed the responses of spleen cells from syngeneic or semisyngeneic mice, C57BL/6 and (C57BL/6 × C3H)F 1 against dinitrophenylated (DNP)-KLH, but not that from C3H mice. The factor from group 2 hybrid cell lines with nonspecific activity suppressed the response of any strains of mice." @default.
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- W20008773 date "1979-01-01" @default.
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- W20008773 title "THE ESTABLISHMENT OF T CELL HYBRIDOMAS WITH SPECIFIC SUPPRESSIVE FUNCTION" @default.
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- W20008773 doi "https://doi.org/10.1016/b978-0-12-069850-9.50075-4" @default.
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