FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000878370> ?p ?o ?g. }

• W2000878370 abstract "Even deadly prions may be widespread in nature if they spread by infection faster than they kill off their hosts. The yeast prions [PSI+] and [URE3] (amyloids of Sup35p and Ure2p) were not found in 70 wild strains, while [PIN+] (amyloid of Rnq1p) was found in ∼16% of the same population. Yeast prion infection occurs only by mating, balancing the detrimental effects of carrying the prion. We estimated the frequency of outcross mating as about 1% of mitotic doublings from the known detriment of carrying the 2-μm DNA plasmid (∼1%) and its frequency in wild populations (38/70). We also estimated the fraction of total matings that are outcross matings (∼23–46%) from the fraction of heterozygosity at the highly polymorphic RNQ1 locus (∼46%). These results show that the detriment of carrying even the mildest forms of [PSI+], [URE3], or [PIN+] is greater than 1%. We find that Rnq1p polymorphisms in wild strains include several premature stop codon alleles that cannot propagate [PIN+] from the reference allele and others with several small deletions and point mutations which show a small transmission barrier. Wild strains carrying [PIN+] are far more likely to be heterozygous at RNQ1 and other loci than are [pin−] strains, probably reflecting its being a sexually transmitted disease. Because sequence differences are known to block prion propagation or ameliorate its pathogenic effects, we hypothesize that polymorphism of RNQ1 was selected to protect cells from detrimental effects of the [PIN+] prion." @default.
• W2000878370 created "2016-06-24" @default.
• W2000878370 creator A5011026810 @default.
• W2000878370 creator A5012149528 @default.
• W2000878370 creator A5051756354 @default.
• W2000878370 creator A5068072238 @default.
• W2000878370 date "2012-09-04" @default.
• W2000878370 modified "2023-09-23" @default.
• W2000878370 title "Sex, prions, and plasmids in yeast" @default.
• W2000878370 cites W1503622815 @default.
• W2000878370 cites W1553457312 @default.
• W2000878370 cites W1787112123 @default.
• W2000878370 cites W1834233095 @default.
• W2000878370 cites W1872122 @default.
• W2000878370 cites W1918460801 @default.
• W2000878370 cites W1966311386 @default.
• W2000878370 cites W1968678331 @default.
• W2000878370 cites W1978750528 @default.
• W2000878370 cites W1979138426 @default.
• W2000878370 cites W1981600273 @default.
• W2000878370 cites W1982603712 @default.
• W2000878370 cites W1989150559 @default.
• W2000878370 cites W1990383225 @default.
• W2000878370 cites W1998427547 @default.
• W2000878370 cites W2001498689 @default.
• W2000878370 cites W2005152235 @default.
• W2000878370 cites W2006813423 @default.
• W2000878370 cites W2010499900 @default.
• W2000878370 cites W2012223842 @default.
• W2000878370 cites W2043676526 @default.
• W2000878370 cites W2046445620 @default.
• W2000878370 cites W2047706498 @default.
• W2000878370 cites W2055169439 @default.
• W2000878370 cites W2062969543 @default.
• W2000878370 cites W2068843220 @default.
• W2000878370 cites W2072029624 @default.
• W2000878370 cites W2072613948 @default.
• W2000878370 cites W2073228699 @default.
• W2000878370 cites W2073533352 @default.
• W2000878370 cites W2073675629 @default.
• W2000878370 cites W2076929447 @default.
• W2000878370 cites W2093611074 @default.
• W2000878370 cites W2093856160 @default.
• W2000878370 cites W2095076518 @default.
• W2000878370 cites W2096586946 @default.
• W2000878370 cites W2096731008 @default.
• W2000878370 cites W2097374545 @default.
• W2000878370 cites W2103725642 @default.
• W2000878370 cites W2105078578 @default.
• W2000878370 cites W2106051171 @default.
• W2000878370 cites W2118285228 @default.
• W2000878370 cites W2118685028 @default.
• W2000878370 cites W2118785256 @default.
• W2000878370 cites W2120640607 @default.
• W2000878370 cites W2124214970 @default.
• W2000878370 cites W2126609745 @default.
• W2000878370 cites W2133529751 @default.
• W2000878370 cites W2136281516 @default.
• W2000878370 cites W2136679442 @default.
• W2000878370 cites W2137495988 @default.
• W2000878370 cites W2137530170 @default.
• W2000878370 cites W2137752713 @default.
• W2000878370 cites W2138390885 @default.
• W2000878370 cites W2138893131 @default.
• W2000878370 cites W2140728946 @default.
• W2000878370 cites W2140784970 @default.
• W2000878370 cites W2143113093 @default.
• W2000878370 cites W2145853549 @default.
• W2000878370 cites W2147180373 @default.
• W2000878370 cites W2154809097 @default.
• W2000878370 cites W2154845780 @default.
• W2000878370 cites W2159577232 @default.
• W2000878370 cites W2165985173 @default.
• W2000878370 cites W2170392103 @default.
• W2000878370 cites W2171381183 @default.
• W2000878370 cites W4240065971 @default.
• W2000878370 doi "https://doi.org/10.1073/pnas.1213449109" @default.
• W2000878370 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3479589" @default.
• W2000878370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22949655" @default.
• W2000878370 hasPublicationYear "2012" @default.
• W2000878370 type Work @default.
• W2000878370 sameAs 2000878370 @default.
• W2000878370 citedByCount "61" @default.
• W2000878370 countsByYear W20008783702012 @default.
• W2000878370 countsByYear W20008783702013 @default.
• W2000878370 countsByYear W20008783702014 @default.
• W2000878370 countsByYear W20008783702015 @default.
• W2000878370 countsByYear W20008783702016 @default.
• W2000878370 countsByYear W20008783702017 @default.
• W2000878370 countsByYear W20008783702018 @default.
• W2000878370 countsByYear W20008783702019 @default.
• W2000878370 countsByYear W20008783702020 @default.
• W2000878370 countsByYear W20008783702021 @default.
• W2000878370 countsByYear W20008783702022 @default.
• W2000878370 countsByYear W20008783702023 @default.
• W2000878370 crossrefType "journal-article" @default.
• W2000878370 hasAuthorship W2000878370A5011026810 @default.
• W2000878370 hasAuthorship W2000878370A5012149528 @default.
• W2000878370 hasAuthorship W2000878370A5051756354 @default.
• W2000878370 hasAuthorship W2000878370A5068072238 @default.

• next