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- W2000878879 abstract "Cells which are in the period of synthesis before mitosis incorporate tritiated thymidine to form desoxyribonucleic acid (DNA).<sup>1,2</sup>It has been assumed that the tritium incorporated into the cell nuclei persists for the life of the cells,<sup>2</sup>but halving of the isotope would occur with each cell division. Cells of tissues with a low mitotic index, such as those of the corneal endothelium,<sup>3</sup>should demonstrate the possibility of indefinite persistence of the isotope. The corneal endothelium of eyes of adult animals could be labeled only during the regeneration which followed mechanical trauma.<sup>4</sup>Corneas labeled in this fashion by other investigators were reported to retain their label for at least five months.<sup>5</sup>In our studies of persistence of donor cells in corneal homografts,<sup>6</sup>destruction of corneal cells by freezing was found to be more advantageous than other kinds of trauma to the cornea. Endothelial cells" @default.
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- W2000878879 date "1966-05-01" @default.
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- W2000878879 title "Four-Year Retention of 3H Thymidine by Corneal Endothelium" @default.
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- W2000878879 doi "https://doi.org/10.1001/archopht.1966.00970050661015" @default.
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