Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000882790> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2000882790 abstract "Prodrugs of isoproterenol, 3-O-,4-O-diacetylisoproterenol (DAI) and 3-O-,4-O-dibenzoylisoproterenol (DBI), were tested for effects on colonic temperature in mice. Intraperitoneal injections of DAI or DBI (20, 50 and 125 mumol/kg) produced a dose-related hypothermia. Isoproterenol (125 mumol/kg) and its metabolite, 3-O-methylisoproterenol (125 mumol/kg), caused hypothermia of a lesser intensity. The involvement of beta-adrenergic receptors in the hypothermic effect of DAI (50 mumol/kg) was established by pretreatments with propranolol and sotalol. The results are discussed in terms of the pharmacodynamics of prodrugs, the pharmacokinetics and mechanism of action of isoproterenol, and the possible role of beta-receptors in temperature regulation. DAI and DBI may be useful as prodrugs for the activation of central beta-receptors." @default.
- W2000882790 created "2016-06-24" @default.
- W2000882790 creator A5001719427 @default.
- W2000882790 creator A5002814870 @default.
- W2000882790 creator A5039255227 @default.
- W2000882790 creator A5048342828 @default.
- W2000882790 date "1981-03-01" @default.
- W2000882790 modified "2023-09-27" @default.
- W2000882790 title "3-O-,4-O-Diacetylisoprotterenol and 3-O-,4-O-dibenzoylisoproterenol: Hypothermic effects in mice and the involvement of β-adrenergic receptors" @default.
- W2000882790 cites W1971222495 @default.
- W2000882790 cites W1989859670 @default.
- W2000882790 cites W1998974462 @default.
- W2000882790 cites W2021264760 @default.
- W2000882790 cites W2030224897 @default.
- W2000882790 cites W2037150326 @default.
- W2000882790 cites W2048634251 @default.
- W2000882790 cites W2058585626 @default.
- W2000882790 cites W2082008462 @default.
- W2000882790 cites W2099589693 @default.
- W2000882790 cites W2147608198 @default.
- W2000882790 cites W2168288316 @default.
- W2000882790 cites W2417564146 @default.
- W2000882790 cites W3176791909 @default.
- W2000882790 cites W88434570 @default.
- W2000882790 doi "https://doi.org/10.1016/0014-2999(81)90216-8" @default.
- W2000882790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6266843" @default.
- W2000882790 hasPublicationYear "1981" @default.
- W2000882790 type Work @default.
- W2000882790 sameAs 2000882790 @default.
- W2000882790 citedByCount "4" @default.
- W2000882790 crossrefType "journal-article" @default.
- W2000882790 hasAuthorship W2000882790A5001719427 @default.
- W2000882790 hasAuthorship W2000882790A5002814870 @default.
- W2000882790 hasAuthorship W2000882790A5039255227 @default.
- W2000882790 hasAuthorship W2000882790A5048342828 @default.
- W2000882790 hasConcept C108215921 @default.
- W2000882790 hasConcept C126322002 @default.
- W2000882790 hasConcept C134018914 @default.
- W2000882790 hasConcept C170493617 @default.
- W2000882790 hasConcept C185592680 @default.
- W2000882790 hasConcept C202751555 @default.
- W2000882790 hasConcept C2776120743 @default.
- W2000882790 hasConcept C2777390192 @default.
- W2000882790 hasConcept C2777477808 @default.
- W2000882790 hasConcept C2778151854 @default.
- W2000882790 hasConcept C40465926 @default.
- W2000882790 hasConcept C55493867 @default.
- W2000882790 hasConcept C71924100 @default.
- W2000882790 hasConcept C98274493 @default.
- W2000882790 hasConceptScore W2000882790C108215921 @default.
- W2000882790 hasConceptScore W2000882790C126322002 @default.
- W2000882790 hasConceptScore W2000882790C134018914 @default.
- W2000882790 hasConceptScore W2000882790C170493617 @default.
- W2000882790 hasConceptScore W2000882790C185592680 @default.
- W2000882790 hasConceptScore W2000882790C202751555 @default.
- W2000882790 hasConceptScore W2000882790C2776120743 @default.
- W2000882790 hasConceptScore W2000882790C2777390192 @default.
- W2000882790 hasConceptScore W2000882790C2777477808 @default.
- W2000882790 hasConceptScore W2000882790C2778151854 @default.
- W2000882790 hasConceptScore W2000882790C40465926 @default.
- W2000882790 hasConceptScore W2000882790C55493867 @default.
- W2000882790 hasConceptScore W2000882790C71924100 @default.
- W2000882790 hasConceptScore W2000882790C98274493 @default.
- W2000882790 hasLocation W20008827901 @default.
- W2000882790 hasLocation W20008827902 @default.
- W2000882790 hasOpenAccess W2000882790 @default.
- W2000882790 hasPrimaryLocation W20008827901 @default.
- W2000882790 hasRelatedWork W1969074476 @default.
- W2000882790 hasRelatedWork W2007079254 @default.
- W2000882790 hasRelatedWork W2023791362 @default.
- W2000882790 hasRelatedWork W2081460129 @default.
- W2000882790 hasRelatedWork W2098248884 @default.
- W2000882790 hasRelatedWork W2116232204 @default.
- W2000882790 hasRelatedWork W2125636877 @default.
- W2000882790 hasRelatedWork W2166067762 @default.
- W2000882790 hasRelatedWork W2183535825 @default.
- W2000882790 hasRelatedWork W2045420005 @default.
- W2000882790 isParatext "false" @default.
- W2000882790 isRetracted "false" @default.
- W2000882790 magId "2000882790" @default.
- W2000882790 workType "article" @default.