FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000883693> ?p ?o ?g. }

• W2000883693 abstract "Intracellular recordings were made from central neurons of Limulus polyphemus and from Retizu cells of the leech, Hirudo medicinalis. The effects of carbachol, amino acids and octopamine were examined on these neurons. Octopamine was found to have a mainly inhibitory effect on a few Limulus neurons. The effects of octopamine were mimicked by clonidine and napthazoline but not by xylazine. Both compounds were slightly more potent than octopamine. Yohimbine, metoclopramide, chlorpromazine and chlordimeform failed to antagonize this octopamine response. The excitatory effect of carbachol was blocked by alpha-bungarotoxin, 10(-7)M. Neither this concentration nor higher concentrations of alpha-bungarotoxin had any effect on L-glutamate excitation. m-Carboxyphenyl derivatives of alanine and glycine acted differentially on Limulus neurons responding to L-glutamate. m- Carboxyphenylglycine only inhibited neurones which showed a biphasic response to L-glutamate while m- carboxyphenylalanine only excited these neurons. Both compounds excited leech Retzius cells, with m- carboxyphenylalanine being about 20 times more potent than m- carboxyphenylglycine . The actions of alpha- ketokainate and allo-alpha- ketokainate were compared to kainate, dihydrokainate and L-glutamate on leech Retzius cells. The equipotent molar ratios for kainate, dihydrokainate , alpha- ketokainate and allo-alpha- ketokainate were 0.0029 +/- 0.0004, 0.021 +/- 0.047, 0.029 +/- 0.005 and 0.14 +/- 0.0093 respectively with L-glutamate as one. All the analogues were more potent than L-glutamate. Quinolinic acid had no glutamate-like activity on either Limulus or Hirudo neurons. Methyltetrahydrofolate was inactive on Limulus neurons but excited leech Retzius cells, being slightly less potent than L-glutamate. Dibutyl cAMP terminated the excitatory actions of kainate on both Limulus and Hirudo neurons. Anisatin , a putative GABA antagonist, was a potent antagonist of GABA inhibition on Limulus neurons." @default.
• W2000883693 created "2016-06-24" @default.
• W2000883693 creator A5031692281 @default.
• W2000883693 creator A5066876673 @default.
• W2000883693 date "1984-01-01" @default.
• W2000883693 modified "2023-09-23" @default.
• W2000883693 title "Neuropharmacological studies on the receptors mediating responses to carbachol, amino acids and octopamine on Limulus and Hirudo central neurons" @default.
• W2000883693 cites W1484082961 @default.
• W2000883693 cites W1504578720 @default.
• W2000883693 cites W1956679421 @default.
• W2000883693 cites W1964213064 @default.
• W2000883693 cites W1966621949 @default.
• W2000883693 cites W1966746287 @default.
• W2000883693 cites W1967536696 @default.
• W2000883693 cites W1976969088 @default.
• W2000883693 cites W1996626550 @default.
• W2000883693 cites W1996889194 @default.
• W2000883693 cites W2008105406 @default.
• W2000883693 cites W2021878979 @default.
• W2000883693 cites W2028885556 @default.
• W2000883693 cites W2034022435 @default.
• W2000883693 cites W2075010970 @default.
• W2000883693 cites W2122339202 @default.
• W2000883693 cites W2313154362 @default.
• W2000883693 cites W2336389835 @default.
• W2000883693 doi "https://doi.org/10.1016/0742-8413(84)90031-8" @default.
• W2000883693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6144446" @default.
• W2000883693 hasPublicationYear "1984" @default.
• W2000883693 type Work @default.
• W2000883693 sameAs 2000883693 @default.
• W2000883693 citedByCount "3" @default.
• W2000883693 crossrefType "journal-article" @default.
• W2000883693 hasAuthorship W2000883693A5031692281 @default.
• W2000883693 hasAuthorship W2000883693A5066876673 @default.
• W2000883693 hasConcept C112592302 @default.
• W2000883693 hasConcept C134018914 @default.
• W2000883693 hasConcept C151730666 @default.
• W2000883693 hasConcept C160268369 @default.
• W2000883693 hasConcept C170493617 @default.
• W2000883693 hasConcept C17077164 @default.
• W2000883693 hasConcept C189184402 @default.
• W2000883693 hasConcept C2776487282 @default.
• W2000883693 hasConcept C2776885963 @default.
• W2000883693 hasConcept C2777676773 @default.
• W2000883693 hasConcept C55493867 @default.
• W2000883693 hasConcept C61174792 @default.
• W2000883693 hasConcept C86803240 @default.
• W2000883693 hasConcept C98274493 @default.
• W2000883693 hasConceptScore W2000883693C112592302 @default.
• W2000883693 hasConceptScore W2000883693C134018914 @default.
• W2000883693 hasConceptScore W2000883693C151730666 @default.
• W2000883693 hasConceptScore W2000883693C160268369 @default.
• W2000883693 hasConceptScore W2000883693C170493617 @default.
• W2000883693 hasConceptScore W2000883693C17077164 @default.
• W2000883693 hasConceptScore W2000883693C189184402 @default.
• W2000883693 hasConceptScore W2000883693C2776487282 @default.
• W2000883693 hasConceptScore W2000883693C2776885963 @default.
• W2000883693 hasConceptScore W2000883693C2777676773 @default.
• W2000883693 hasConceptScore W2000883693C55493867 @default.
• W2000883693 hasConceptScore W2000883693C61174792 @default.
• W2000883693 hasConceptScore W2000883693C86803240 @default.
• W2000883693 hasConceptScore W2000883693C98274493 @default.
• W2000883693 hasLocation W20008836931 @default.
• W2000883693 hasLocation W20008836932 @default.
• W2000883693 hasOpenAccess W2000883693 @default.
• W2000883693 hasPrimaryLocation W20008836931 @default.
• W2000883693 hasRelatedWork W176630655 @default.
• W2000883693 hasRelatedWork W1966691812 @default.
• W2000883693 hasRelatedWork W1985332166 @default.
• W2000883693 hasRelatedWork W1992933456 @default.
• W2000883693 hasRelatedWork W1993739730 @default.
• W2000883693 hasRelatedWork W1999315981 @default.
• W2000883693 hasRelatedWork W2000883693 @default.
• W2000883693 hasRelatedWork W2411662560 @default.
• W2000883693 hasRelatedWork W2810445864 @default.
• W2000883693 hasRelatedWork W46252910 @default.
• W2000883693 isParatext "false" @default.
• W2000883693 isRetracted "false" @default.
• W2000883693 magId "2000883693" @default.
• W2000883693 workType "article" @default.