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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000883904> ?p ?o ?g. }

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• W2000883904 abstract "To clarify the chondrocyte-specific regulatory mechanism of connective tissue growth factor (ctgf) gene expression, we analyzed the functionality and DNA-protein interaction of the CTGF promoter. Comparative luciferase assay of the CTGF promoter deletion mutants among HCS-2/8 chondrocytic cells and fibroblastic cells revealed that a 110-bp region in the promoter was crucial for the HCS-2/8-specific transcriptional enhancement. Subsequent competitive gel shift assay revealed that transcription factors in HCS-2/8 nuclei bound to a 60-bp portion in the corresponding region. Relative luciferase activity from a CTGF promoter with mutant TGF-beta response element (TbRE) was 16.9% lower than that from an intact promoter. On the other hand, relative luciferase activity from a CTGF promoter with 4bp point mutations at 30bp upstream of the TbRE was 47.7% lower than that from the intact one. The binding activity of HCS-2/8 nuclear factor(s) to the sequence over the 4-bp was remarkably higher than that of any nuclear extract from other types of cells. Therefore, we entitled the sequence 'TRENDIC', a transcription enhancer dominant in chondrocytes, which stands for a novel enhancer for chondrocyte-specific CTGF gene expression." @default.
• W2000883904 created "2016-06-24" @default.
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• W2000883904 date "2002-07-01" @default.
• W2000883904 modified "2023-09-23" @default.
• W2000883904 title "A novel cis-element that enhances connective tissue growth factor gene expression in chondrocytic cells" @default.
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• W2000883904 doi "https://doi.org/10.1016/s0006-291x(02)00700-3" @default.
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