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- W2000884246 abstract "The daily administration of a hyperphysiological, nontoxic level (10 mg/kg) of hexestrol to mice, for 6 consecutive days, progressively lowered the capacity of hepatic tissue to synthesize NAD upon nicotinamide challenge. The degree of inhibition of NAD synthesis was correlated with a decrease in the nicotinamide deamidase activity of the tissue. Hepatic nicotinamide deamidase activity was also lowered by equimolar amounts of dienestrol, diethylstilbestrol, estradiol-17β, estrone, estriol, cortisone, and hydrocortisone. All the compounds that decreased the hepatic nicotinamide deamidase also lowered the capacity of hepatic tissue to synthesize NAD upon nicotinamide challenge." @default.
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- W2000884246 date "1965-04-01" @default.
- W2000884246 modified "2023-09-23" @default.
- W2000884246 title "Effect of hyperphysiological levels of steroid hormones on nicotinamide deamidase and NAD synthesis in mouse liver tissue" @default.
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- W2000884246 doi "https://doi.org/10.1016/0006-2952(65)90219-4" @default.
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