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- W2000886444 abstract "Polymeric polyesters such as the polylactides are well-suited for use as radiopharmaceuticals since they are biocompatible, non-toxic, and biodegrade in a controlled manner, according to their molecular weight and structure (1). They can be formed into nanospheres, microspheres, magnetic microspheres, polymeric sheets, and even into a gel that solidifies on contact with tissue (2). We synthesized new chelator-containing derivatives of poly(lactic acid) which have very similar physical properties to the unaltered polymer. Thus microspheres, capable of binding diagnostic and therapeutic radioisotopes in a fast and reliable fashion with high binding stability, can be formed out of these modified polylactides. Immediate applications for these microspheres radiolabeled with Tc or In are in diagnostic imaging. They can also be used as carriers of therapeutic radioisotopes, such as Re, Re, Y, Dy, Sm, and Ho to treat small amounts of residual solid tumor after maximal surgery of, for example, pancreatic carcinomas and glioblastomas." @default.
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- W2000886444 date "2001-05-01" @default.
- W2000886444 modified "2023-09-27" @default.
- W2000886444 title "Novel chelator containing particles specific for controlled radioisotope delivery" @default.
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- W2000886444 doi "https://doi.org/10.1002/jlcr.25804401294" @default.
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