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• W2000886481 abstract "We studied the interaction of cis ‐diammine Pt(II)‐bridged bis‐netropsin, cis ‐diammine Pt(II)‐bridged bis‐distamycin and oligomethylene‐bridged bis‐netropsin with synthetic DNA fragments containing pseudosymmetrical AT‐rich nucleotide sequences and compared it with the interaction of the parent compounds netropsin and distamycin A. For fragments containing multiple blocks of (A/T) 4 and (T/A) 4 separated by zero, one, two and three GC‐base pairs, DNase I footprinting and CD spectroscopy studies reveal that 5′‐TTTTAAAA‐3′ is the strongest affinity binding site for cis ‐diammine Pt(II)‐bridged bis‐netropsin and bis‐distamycin. They both bind less strongly to a DNA region containing the sequence 5′‐AAAATTTT‐3′. Netropsin, distamycin A and oligomethylene‐bridged bis‐netropsin exhibit far less sequence discrimination." @default.
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• W2000886481 date "1998-11-20" @default.
• W2000886481 modified "2023-09-27" @default.
• W2000886481 title "DNA sequence recognition by bis-linked netropsin and distamycin derivatives" @default.
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• W2000886481 doi "https://doi.org/10.1016/s0014-5793(98)01379-9" @default.
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