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- W2000887445 abstract "Both experimental and clinical data indicate that coagulation disorders may affect patients with cancer, even though clinical symptoms occur in a very small percentage of subjects. Prothrombin Time (PT), Partial Thromboplastin Time (PPT), Anti-Thrombin III (AT-III), Platelet Count (PC), Fibrinogen (F), and D-Dimer (DD) were prospectively recorded from a series of 287 consecutive patients with a new primary LC. Other variables (in all, 39) included anthropometric, clinical, physical, laboratory, radiological, and pathologic tumour findings, as well as the subsequent clinical course. Spearman rank correlation between coagulation factors were weakly significant, or, more often, nonsignificant (the correlation index between PT and PTT, the best one, was −0.25, P = 0.0000). Univariate survival analyses showed that lower values of PT ( P = 0.003), and PTT ( P = 0.06), and higher values of F ( P = 0.001) and DD ( P = 0.00002) were all associated with a poor prognosis. Few, weak correlations between other well-established prognostic variables (stage of disease excluded) and coagulation factors were found. Because of the weakness of this correlation pattern, coagulation factors resulted as important independent survival predictors in any of the Cox’ model regression analyses attempted, whatever the number of co-factors was." @default.
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- W2000887445 date "1995-11-01" @default.
- W2000887445 modified "2023-09-25" @default.
- W2000887445 title "1056 Pre-thrombotic state is a strong unfavorable indicator of lung cancer (LC) prognosis: Results from a prospective study" @default.
- W2000887445 doi "https://doi.org/10.1016/0959-8049(95)96304-v" @default.
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