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- W2000887809 abstract "Alginate is an important virulence factor in Pseudomonas aeruginosa, an ubiquitous bacterium which produces this particular exopolysaccharide almost exclusively in association with chronic respiratory infections in cystic fibrosis. Evidence suggests that the respiratory tract is initially colonized by non-mucoid P. aeruginosa strains, which are converted into the mucoid phenotype by production of alginate. This synthesis is extensively regulated by environmental factors, and a number of biosynthetic and regulatory genes have been identified. The transcriptional activation of the algD gene promoter is the key point in this regulation. It requires an alternative sigma factor and other activating factors which affect the switch to the mucoid phenotype and the level of expression of algD. Selection of genetic rearrangements conferring a mucoid character upon P. aeruginosa could be influenced by particular environment conditions." @default.
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- W2000887809 date "1996-01-01" @default.
- W2000887809 modified "2023-09-23" @default.
- W2000887809 title "La biosynthèse des alginates chez Pseudomonas aeruginosa: Régulation de l'expression d'un facteur de virulence" @default.
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- W2000887809 doi "https://doi.org/10.1016/0020-2452(96)81740-4" @default.
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