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• W2000888118 abstract "Two decades of research conclusively demonstrated the antithrombotic properties of the long-chain n-3 polyunsaturated fatty acids (PUFA) present in lipids from marine fishes. Most American consumers, however, given their preference for meat, will not realize the benefits of a fish-rich diet. Could α-linolenic acid (18:3, n-3) be similarly effective via modulation of the synthesis of vasoactive eicosanoids, i.e., thromboxane and prostacyclin? The present pilot study is a contribution toward answering this question. We determined that the urinary excretion of 11-dehydrothromboxane B2 declined by 34% from baseline level 7 weeks after the ratio of dietary PUFA was reduced from 28:1 to 1:1. The excretion of 2,3-dinor-6-oxo-prostaglandin F1α was similarly affected. The dietary adjustment was brought about by substituting measured amounts of canola and flaxseed oils (3:1) for measured amounts of olive and corn oils (3:1) in an otherwise fat-free basal diet. This study demonstrates that dietary α-linolenic acid is an effective modulator of thromboxane and prostacyclin biosynthesis. Therefore, we can expect that the eicosanoid-mediated effects of α-linolenic acid are similar to those elicited by marine lipids." @default.
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• W2000888118 date "1996-06-01" @default.
• W2000888118 modified "2023-09-23" @default.
• W2000888118 title "Antithromboxane activity of dietary alpha-linolenic acid: a pilot study" @default.
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• W2000888118 doi "https://doi.org/10.1016/s0952-3278(96)90030-7" @default.
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