FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000888252> ?p ?o ?g. }

• W2000888252 endingPage "411" @default.
• W2000888252 startingPage "411" @default.
• W2000888252 abstract "Stress is linked to a wide variety of psychological and somatic ailments, including affective diseases (such as depression) and post-traumatic stress disorder. In recent years it has become increasingly clear that the impact of stress on pathology varies substantially from individual to individual (McEwen & Stellar, 1993; Radley et al., 2011). Defining mechanisms underlying individual differences is crucial to understanding the biological basis of stress control and using this knowledge to develop treatment strategies for stress-related diseases. This issue of European Journal of Neuroscience, Knapman et al. (2012) use state-of-the-art imaging methods and proteomics to explore neural events associated with differential stress reactivity in strains of mice selected for low, intermediate and high stress reactivity, as defined by the magnitude of corticosteroid responses to acute stressors. The strain with the greatest corticosterone reactivity to stress has memory deficits that are accompanied by lateralized reductions in hippocampal N-acetyl aspartate (NAA), reduced basal activity in the hippocampus and alterations in expression of hippocampal proteins regulating cellular energy metabolism. The data indicate a novel connection between susceptibility to stress and hippocampal (and perhaps cortical) metabolic function, suggesting mitochondrial dysfunction as a possible mechanism for stress vulnerability and, by extension, stressrelated disease processes. It is generally recognized that animal models of psychiatric disorders are problematic. The (always limited) validity of a model will depend on how well it matches the human disorder. For psychiatric disorders, features related to brain structure, metabolism and function will obviously be of primary relevance and interest. Beyond the implications for individual differences, this work demonstrates the power of advanced magnetic resonance techniques to probe in vivo metabolism and neuronal activity. NAA is now generally accepted as a relatively non-specific marker of neuronal integrity and mitochondrial metabolism (de Graaf, 2007). The value of magnetic resonance spectroscopy (MRS) lies in its ability to measure NAA (and several other major metabolites not probed in the present work) non-invasively and longitudinally in brain in both humans and animal models under a variety of parallel diagnostic criteria and treatment conditions. Longitudinal measures are of particular relevance for mechanistic approaches in animals, where one can achieve ‘before and after’ measurements associated with experimental interventions or genetic manipulations. Moreover, metabolic and functional measures may become clinically relevant at the early stages of a neurochemical disorder, before volume changes in the brain are apparent. Beyond MRS, manganese-enhanced magnetic resonance imaging, although not likely to be applicable to human studies, is becoming a useful adjunct to anatomical magnetic resonance imaging (Inoue et al., 2011) that can provide a crude but unique measure of the functional status of neuronal pathways. Studies like that of Knapman et al. (2012) can bridge the gap between detailed biochemical ⁄ proteomic analysis in animal models and dynamic functional ⁄metabolic measures in the human brain." @default.
• W2000888252 created "2016-06-24" @default.
• W2000888252 creator A5008140269 @default.
• W2000888252 creator A5056855507 @default.
• W2000888252 creator A5082531791 @default.
• W2000888252 date "2012-01-31" @default.
• W2000888252 modified "2023-09-26" @default.
• W2000888252 title "Linking cerebral metabolic function to stress vulnerability (Commentary on Knapman et al.)" @default.
• W2000888252 cites W1982835526 @default.
• W2000888252 cites W2037670227 @default.
• W2000888252 cites W2144879545 @default.
• W2000888252 cites W2161771013 @default.
• W2000888252 cites W4246406957 @default.
• W2000888252 doi "https://doi.org/10.1111/j.1460-9568.2012.08004.x" @default.
• W2000888252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22288478" @default.
• W2000888252 hasPublicationYear "2012" @default.
• W2000888252 type Work @default.
• W2000888252 sameAs 2000888252 @default.
• W2000888252 citedByCount "0" @default.
• W2000888252 crossrefType "journal-article" @default.
• W2000888252 hasAuthorship W2000888252A5008140269 @default.
• W2000888252 hasAuthorship W2000888252A5056855507 @default.
• W2000888252 hasAuthorship W2000888252A5082531791 @default.
• W2000888252 hasConcept C14036430 @default.
• W2000888252 hasConcept C15744967 @default.
• W2000888252 hasConcept C169760540 @default.
• W2000888252 hasConcept C188147891 @default.
• W2000888252 hasConcept C3018390542 @default.
• W2000888252 hasConcept C38652104 @default.
• W2000888252 hasConcept C41008148 @default.
• W2000888252 hasConcept C78458016 @default.
• W2000888252 hasConcept C86803240 @default.
• W2000888252 hasConcept C95713431 @default.
• W2000888252 hasConceptScore W2000888252C14036430 @default.
• W2000888252 hasConceptScore W2000888252C15744967 @default.
• W2000888252 hasConceptScore W2000888252C169760540 @default.
• W2000888252 hasConceptScore W2000888252C188147891 @default.
• W2000888252 hasConceptScore W2000888252C3018390542 @default.
• W2000888252 hasConceptScore W2000888252C38652104 @default.
• W2000888252 hasConceptScore W2000888252C41008148 @default.
• W2000888252 hasConceptScore W2000888252C78458016 @default.
• W2000888252 hasConceptScore W2000888252C86803240 @default.
• W2000888252 hasConceptScore W2000888252C95713431 @default.
• W2000888252 hasIssue "3" @default.
• W2000888252 hasLocation W20008882521 @default.
• W2000888252 hasLocation W20008882522 @default.
• W2000888252 hasOpenAccess W2000888252 @default.
• W2000888252 hasPrimaryLocation W20008882521 @default.
• W2000888252 hasRelatedWork W1982234005 @default.
• W2000888252 hasRelatedWork W1999264800 @default.
• W2000888252 hasRelatedWork W2004289737 @default.
• W2000888252 hasRelatedWork W2058067351 @default.
• W2000888252 hasRelatedWork W2098827876 @default.
• W2000888252 hasRelatedWork W2321960612 @default.
• W2000888252 hasRelatedWork W2984911552 @default.
• W2000888252 hasRelatedWork W3096540848 @default.
• W2000888252 hasRelatedWork W3191807991 @default.
• W2000888252 hasRelatedWork W939404165 @default.
• W2000888252 hasVolume "35" @default.
• W2000888252 isParatext "false" @default.
• W2000888252 isRetracted "false" @default.
• W2000888252 magId "2000888252" @default.
• W2000888252 workType "article" @default.