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- W2000889477 abstract "The therapeutic landscape for mycotic infections is shifting. New generation azoles that are active against clinically relevant, drug-resistant fungal pathogens have improved bioavailability, half-lives and safety profiles. Acylated cyclic peptide inhibitors of beta(1,3)glucan synthesis with origins as fungal metabolites provide an alternative and highly-selective mode of action, targeting cell-wall biogenesis in important pathogens such as Candida and Aspergillus species. The development, in each structural class, of compounds that have advanced to late-stage clinical trials is summarized in this review." @default.
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- W2000889477 date "2001-10-01" @default.
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- W2000889477 title "Antifungals: what's in the pipeline" @default.
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- W2000889477 doi "https://doi.org/10.1016/s1369-5274(00)00248-4" @default.
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