FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000889999> ?p ?o ?g. }

• W2000889999 endingPage "1268" @default.
• W2000889999 startingPage "1257" @default.
• W2000889999 abstract "BackgroundA conserved biological feature of sexual reproduction in animals is that oocytes arrest in meiotic prophase and resume meiosis in response to extraovarian signals. In C. elegans, sperm trigger meiotic resumption by means of the major sperm protein (MSP) signal. MSP promotes meiotic resumption by functioning as an ephrin-signaling antagonist and by counteracting inhibitory inputs from the somatic gonadal sheath cells.ResultsBy using a genome-wide RNAi screen in a female-sterile genetic background, we identified 17 conserved genes that maintain meiotic arrest in the absence of the MSP signal. In vitro binding experiments show that MSP promotes oocyte mitogen-activated protein kinase activation and meiotic maturation in part through direct interaction with the VAB-1 Eph receptor. Four conserved proteins, including a disabled protein (DAB-1), a vav family GEF (VAV-1), a protein kinase C (PKC-1), and a STAM homolog (PQN-19), function with the VAB-1 Eph/MSP receptor in oocytes. We show that antagonistic Gαo/i and Gαs signaling pathways function in the soma to regulate meiotic maturation in parallel to the VAB-1 pathway. Gαs activity is necessary and sufficient to promote meiotic maturation, which it does in part by antagonizing inhibitory sheath/oocyte gap-junctional communication.ConclusionsOur findings show that oocyte Eph receptor and somatic cell G protein signaling pathways control meiotic diapause in C. elegans, highlighting contrasts and parallels between MSP signaling in C. elegans and luteinizing hormone signaling in mammals." @default.
• W2000889999 created "2016-06-24" @default.
• W2000889999 creator A5001547259 @default.
• W2000889999 creator A5066960553 @default.
• W2000889999 creator A5068974302 @default.
• W2000889999 creator A5072524619 @default.
• W2000889999 date "2006-07-01" @default.
• W2000889999 modified "2023-10-01" @default.
• W2000889999 title "Gαo/i and Gαs Signaling Function in Parallel with the MSP/Eph Receptor to Control Meiotic Diapause in C. elegans" @default.
• W2000889999 cites W1529934215 @default.
• W2000889999 cites W1531366679 @default.
• W2000889999 cites W1952185161 @default.
• W2000889999 cites W1969030895 @default.
• W2000889999 cites W1974931752 @default.
• W2000889999 cites W1986140299 @default.
• W2000889999 cites W1991877215 @default.
• W2000889999 cites W1992622314 @default.
• W2000889999 cites W1993678582 @default.
• W2000889999 cites W2001801169 @default.
• W2000889999 cites W2004020532 @default.
• W2000889999 cites W2004302606 @default.
• W2000889999 cites W2007819876 @default.
• W2000889999 cites W2011014082 @default.
• W2000889999 cites W2018430478 @default.
• W2000889999 cites W2026068903 @default.
• W2000889999 cites W2031847595 @default.
• W2000889999 cites W2032325024 @default.
• W2000889999 cites W2034924573 @default.
• W2000889999 cites W2040392785 @default.
• W2000889999 cites W2053933456 @default.
• W2000889999 cites W2054167608 @default.
• W2000889999 cites W2059911455 @default.
• W2000889999 cites W2064261581 @default.
• W2000889999 cites W2075552931 @default.
• W2000889999 cites W2078290278 @default.
• W2000889999 cites W2084172300 @default.
• W2000889999 cites W2100512407 @default.
• W2000889999 cites W2106742994 @default.
• W2000889999 cites W2128288344 @default.
• W2000889999 cites W2129533258 @default.
• W2000889999 cites W2132767295 @default.
• W2000889999 cites W2135587043 @default.
• W2000889999 cites W2140217146 @default.
• W2000889999 cites W2140420250 @default.
• W2000889999 cites W2153559788 @default.
• W2000889999 cites W2154166273 @default.
• W2000889999 cites W2158387009 @default.
• W2000889999 cites W2163174772 @default.
• W2000889999 cites W2166989247 @default.
• W2000889999 cites W2170254044 @default.
• W2000889999 cites W2183709303 @default.
• W2000889999 doi "https://doi.org/10.1016/j.cub.2006.05.020" @default.
• W2000889999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16824915" @default.
• W2000889999 hasPublicationYear "2006" @default.
• W2000889999 type Work @default.
• W2000889999 sameAs 2000889999 @default.
• W2000889999 citedByCount "99" @default.
• W2000889999 countsByYear W20008899992012 @default.
• W2000889999 countsByYear W20008899992013 @default.
• W2000889999 countsByYear W20008899992014 @default.
• W2000889999 countsByYear W20008899992015 @default.
• W2000889999 countsByYear W20008899992016 @default.
• W2000889999 countsByYear W20008899992017 @default.
• W2000889999 countsByYear W20008899992018 @default.
• W2000889999 countsByYear W20008899992019 @default.
• W2000889999 countsByYear W20008899992020 @default.
• W2000889999 countsByYear W20008899992021 @default.
• W2000889999 countsByYear W20008899992022 @default.
• W2000889999 countsByYear W20008899992023 @default.
• W2000889999 crossrefType "journal-article" @default.
• W2000889999 hasAuthorship W2000889999A5001547259 @default.
• W2000889999 hasAuthorship W2000889999A5066960553 @default.
• W2000889999 hasAuthorship W2000889999A5068974302 @default.
• W2000889999 hasAuthorship W2000889999A5072524619 @default.
• W2000889999 hasBestOaLocation W20008899991 @default.
• W2000889999 hasConcept C101544691 @default.
• W2000889999 hasConcept C104317684 @default.
• W2000889999 hasConcept C134305767 @default.
• W2000889999 hasConcept C148196450 @default.
• W2000889999 hasConcept C170286479 @default.
• W2000889999 hasConcept C184235292 @default.
• W2000889999 hasConcept C19331615 @default.
• W2000889999 hasConcept C196843134 @default.
• W2000889999 hasConcept C2776690073 @default.
• W2000889999 hasConcept C2778944004 @default.
• W2000889999 hasConcept C2781087480 @default.
• W2000889999 hasConcept C54355233 @default.
• W2000889999 hasConcept C62478195 @default.
• W2000889999 hasConcept C86803240 @default.
• W2000889999 hasConcept C95444343 @default.
• W2000889999 hasConcept C97029542 @default.
• W2000889999 hasConceptScore W2000889999C101544691 @default.
• W2000889999 hasConceptScore W2000889999C104317684 @default.
• W2000889999 hasConceptScore W2000889999C134305767 @default.
• W2000889999 hasConceptScore W2000889999C148196450 @default.
• W2000889999 hasConceptScore W2000889999C170286479 @default.
• W2000889999 hasConceptScore W2000889999C184235292 @default.
• W2000889999 hasConceptScore W2000889999C19331615 @default.

• next