FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000890273> ?p ?o ?g. }

• W2000890273 endingPage "1164" @default.
• W2000890273 startingPage "1155" @default.
• W2000890273 abstract "Gouania longipetala leaves are commonly used in folkloric medicine in Africa and other parts of the world for treatment of edema, febrifuges, veneral diseases, lumbago, heart diseases, diabetes mellitus malaria, etc. This study therefore evaluated safety profile of the methanol leaf extract of the plant using acute and sub-chronic studies in rat model.Acute toxicity test of the plant lasted for 48 h with oral administration of graded doses (100-4000 mg/kg) of Gouania longipetala extract (GLE) in rats. The rats were observed for signs of toxicity and death. The sub-chronic toxicity was evaluated by administration of different doses (2.5, 5 and 10 mg/kg) of GLE daily in feed for 90 days. On days, 30, 60 and 90, blood samples collected from the retro-orbital plexus of the eye of the rats were used for evaluation of serum biochemistry, hematology, lipid peroxidation and in vivo antioxidant activities. Histopathological evaluations of the kidney, liver, lungs and heart were also done.The acute toxicity test revealed no observable signs of toxicity or morbidity. Sub-chronic study showed that GLE significantly (p<0.05) increased relative liver weight on day 90 at 10 mg/kg. There were no significant variations in the hematological parameters of both GLE treated and untreated rats. The extract significantly (p<0.05) reduced total cholesterol, triglycerides, very low density lipoproteins and increased high density lipoproteins which was more prominent on day 90 at the dose of 10 mg/kg. The extract significantly (p<0.05) increased liver enzyme markers at the doses used. GLE also significantly (p<0.05) increased serum urea at the dose of 10 mg/kg on day 90. The extract caused dose-dependent and significant (p<0.05) increase in superoxide dismutase and decrease in malondiadehyde. Histopathological studies revealed degenerative changes in the kidney and liver.The results of the study suggest that Gouania longipetala is well tolerated in short term therapies, but may have long term toxic effects on the kidney and liver." @default.
• W2000890273 created "2016-06-24" @default.
• W2000890273 creator A5037100873 @default.
• W2000890273 creator A5052909158 @default.
• W2000890273 creator A5067958538 @default.
• W2000890273 date "2014-02-01" @default.
• W2000890273 modified "2023-10-01" @default.
• W2000890273 title "Acute and sub-chronic toxicity profile of methanol leaf extract of Gouania longipetala in rats" @default.
• W2000890273 cites W1538399032 @default.
• W2000890273 cites W1550111394 @default.
• W2000890273 cites W1895532472 @default.
• W2000890273 cites W1946263363 @default.
• W2000890273 cites W1976086787 @default.
• W2000890273 cites W1978567215 @default.
• W2000890273 cites W1985655598 @default.
• W2000890273 cites W1992745272 @default.
• W2000890273 cites W2007991942 @default.
• W2000890273 cites W2011192430 @default.
• W2000890273 cites W2042213831 @default.
• W2000890273 cites W2042464457 @default.
• W2000890273 cites W2043885779 @default.
• W2000890273 cites W2046233608 @default.
• W2000890273 cites W2047718984 @default.
• W2000890273 cites W2049702067 @default.
• W2000890273 cites W2059330850 @default.
• W2000890273 cites W2059869911 @default.
• W2000890273 cites W2076802435 @default.
• W2000890273 cites W2081568627 @default.
• W2000890273 cites W2084437748 @default.
• W2000890273 cites W2095777125 @default.
• W2000890273 cites W2098847957 @default.
• W2000890273 cites W2107994706 @default.
• W2000890273 cites W2123409005 @default.
• W2000890273 cites W2263023695 @default.
• W2000890273 doi "https://doi.org/10.1016/j.jep.2013.12.034" @default.
• W2000890273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24384377" @default.
• W2000890273 hasPublicationYear "2014" @default.
• W2000890273 type Work @default.
• W2000890273 sameAs 2000890273 @default.
• W2000890273 citedByCount "76" @default.
• W2000890273 countsByYear W20008902732014 @default.
• W2000890273 countsByYear W20008902732015 @default.
• W2000890273 countsByYear W20008902732016 @default.
• W2000890273 countsByYear W20008902732017 @default.
• W2000890273 countsByYear W20008902732018 @default.
• W2000890273 countsByYear W20008902732019 @default.
• W2000890273 countsByYear W20008902732020 @default.
• W2000890273 countsByYear W20008902732021 @default.
• W2000890273 countsByYear W20008902732022 @default.
• W2000890273 countsByYear W20008902732023 @default.
• W2000890273 crossrefType "journal-article" @default.
• W2000890273 hasAuthorship W2000890273A5037100873 @default.
• W2000890273 hasAuthorship W2000890273A5052909158 @default.
• W2000890273 hasAuthorship W2000890273A5067958538 @default.
• W2000890273 hasConcept C116263406 @default.
• W2000890273 hasConcept C126322002 @default.
• W2000890273 hasConcept C134018914 @default.
• W2000890273 hasConcept C150903083 @default.
• W2000890273 hasConcept C167552308 @default.
• W2000890273 hasConcept C185592680 @default.
• W2000890273 hasConcept C207001950 @default.
• W2000890273 hasConcept C2776151105 @default.
• W2000890273 hasConcept C2777056448 @default.
• W2000890273 hasConcept C2778004101 @default.
• W2000890273 hasConcept C2778163477 @default.
• W2000890273 hasConcept C2778270857 @default.
• W2000890273 hasConcept C2780829032 @default.
• W2000890273 hasConcept C2780886150 @default.
• W2000890273 hasConcept C29730261 @default.
• W2000890273 hasConcept C53164099 @default.
• W2000890273 hasConcept C55493867 @default.
• W2000890273 hasConcept C555293320 @default.
• W2000890273 hasConcept C556039675 @default.
• W2000890273 hasConcept C71924100 @default.
• W2000890273 hasConcept C86803240 @default.
• W2000890273 hasConcept C98274493 @default.
• W2000890273 hasConceptScore W2000890273C116263406 @default.
• W2000890273 hasConceptScore W2000890273C126322002 @default.
• W2000890273 hasConceptScore W2000890273C134018914 @default.
• W2000890273 hasConceptScore W2000890273C150903083 @default.
• W2000890273 hasConceptScore W2000890273C167552308 @default.
• W2000890273 hasConceptScore W2000890273C185592680 @default.
• W2000890273 hasConceptScore W2000890273C207001950 @default.
• W2000890273 hasConceptScore W2000890273C2776151105 @default.
• W2000890273 hasConceptScore W2000890273C2777056448 @default.
• W2000890273 hasConceptScore W2000890273C2778004101 @default.
• W2000890273 hasConceptScore W2000890273C2778163477 @default.
• W2000890273 hasConceptScore W2000890273C2778270857 @default.
• W2000890273 hasConceptScore W2000890273C2780829032 @default.
• W2000890273 hasConceptScore W2000890273C2780886150 @default.
• W2000890273 hasConceptScore W2000890273C29730261 @default.
• W2000890273 hasConceptScore W2000890273C53164099 @default.
• W2000890273 hasConceptScore W2000890273C55493867 @default.
• W2000890273 hasConceptScore W2000890273C555293320 @default.
• W2000890273 hasConceptScore W2000890273C556039675 @default.
• W2000890273 hasConceptScore W2000890273C71924100 @default.
• W2000890273 hasConceptScore W2000890273C86803240 @default.
• W2000890273 hasConceptScore W2000890273C98274493 @default.

• next