FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000891017> ?p ?o ?g. }

• W2000891017 endingPage "1223" @default.
• W2000891017 startingPage "1218" @default.
• W2000891017 abstract "Objective: Helicobacter pylori (H. pylori) causes chronic gastritis. The inducible prostaglandin synthetase cyclooxygenase 2 (COX-2) plays an important role in inflammatory conditions. We hypothesized that H. pylori-associated chronic gastritis would express COX-2 protein. Our aim was to evaluate the effect of eradication of H. pylori infection on COX-2 expression in the antral mucosa of patients before and after antibiotic therapy. Methods: Tissues were obtained from patients with nonulcer dyspepia undergoing H. pylori eradication. Ten patients with proven H. pylori infection and subsequent successful eradication were studied. Three biopsies of antral mucosa were evaluated before and after H. pylori eradication. The amount of acute and chronic inflammation was quantitated. Immunohistochemical staining for COX-2 was expressed as a percentage of the total number of cells and correlated with the degree of chronic inflammation. Results: Specific immunostaining for COX-2 was observed in antral mucosa of patients infected with H. pylori. Patchy cytoplasmic staining was seen in surface epithelial cells and strong cytoplasmic staining for COX-2 was seen in parietal cells. Spotty cytoplasmic staining for COX-2 was also seen in lamina propria plasma cells, as well as there being macrophages present in the germinal centers of lymphoid aggregates. COX-2 expression could be detected both before and after eradication of H. pylori. The mean percentage of cells staining for COX-2 was significantly higher in H. pylori-infected mucosa, compared with mucosa after successful H. pylori eradication (33.4%± 5.4 vs 18.9%± 3.3, p= 0.038). COX-2 immunostaining correlated best with the chronic inflammation score (r2= 0.78, p < 0.001). There was a strong correlation for those subjects who were H. pylori infected, as well as for those who had successful H. pylori eradication. Conclusions: H. pylori associated acute and chronic antral inflammation was associated with immunohistochemical detection of COX-2 protein in epithelial cells, in addition to associated mononuclear cells and parietal cells. Expression was reduced, but not eliminated, in the epithelium after successful eradication of H. pylori. Despite the reduction in COX-2 expression after H. pylori eradication, expression of COX-2 in epithelial cells remained and strongly correlated with the extent of the chronic inflammatory cell infiltrate. The clinical implications of H. pylori-associated induction of COX-2 expression for patients on selective COX-2 inhibitors, in addition to the role of COX-2 in gastric carcinogenesis, deserve further study." @default.
• W2000891017 created "2016-06-24" @default.
• W2000891017 creator A5069490679 @default.
• W2000891017 creator A5071003340 @default.
• W2000891017 creator A5079437075 @default.
• W2000891017 creator A5085891308 @default.
• W2000891017 date "1999-05-01" @default.
• W2000891017 modified "2023-10-15" @default.
• W2000891017 title "Cyclooxygenase-2 Expression in Gastric Antral Mucosa Before and After Eradication of Helicobacter Pylori Infection" @default.
• W2000891017 cites W1967243859 @default.
• W2000891017 cites W1968219794 @default.
• W2000891017 cites W1989346932 @default.
• W2000891017 cites W2039440412 @default.
• W2000891017 cites W2049139460 @default.
• W2000891017 cites W2076718515 @default.
• W2000891017 cites W2156470937 @default.
• W2000891017 cites W2157782064 @default.
• W2000891017 cites W2333044470 @default.
• W2000891017 doi "https://doi.org/10.1111/j.1572-0241.1999.01070.x" @default.
• W2000891017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10235197" @default.
• W2000891017 hasPublicationYear "1999" @default.
• W2000891017 type Work @default.
• W2000891017 sameAs 2000891017 @default.
• W2000891017 citedByCount "142" @default.
• W2000891017 countsByYear W20008910172012 @default.
• W2000891017 countsByYear W20008910172014 @default.
• W2000891017 countsByYear W20008910172015 @default.
• W2000891017 countsByYear W20008910172016 @default.
• W2000891017 countsByYear W20008910172017 @default.
• W2000891017 countsByYear W20008910172018 @default.
• W2000891017 countsByYear W20008910172020 @default.
• W2000891017 crossrefType "journal-article" @default.
• W2000891017 hasAuthorship W2000891017A5069490679 @default.
• W2000891017 hasAuthorship W2000891017A5071003340 @default.
• W2000891017 hasAuthorship W2000891017A5079437075 @default.
• W2000891017 hasAuthorship W2000891017A5085891308 @default.
• W2000891017 hasBestOaLocation W20008910172 @default.
• W2000891017 hasConcept C126322002 @default.
• W2000891017 hasConcept C131253125 @default.
• W2000891017 hasConcept C142724271 @default.
• W2000891017 hasConcept C181199279 @default.
• W2000891017 hasConcept C204232928 @default.
• W2000891017 hasConcept C2776409635 @default.
• W2000891017 hasConcept C2776914184 @default.
• W2000891017 hasConcept C2777310793 @default.
• W2000891017 hasConcept C2778677798 @default.
• W2000891017 hasConcept C2779422922 @default.
• W2000891017 hasConcept C2779689624 @default.
• W2000891017 hasConcept C2780561475 @default.
• W2000891017 hasConcept C2781443798 @default.
• W2000891017 hasConcept C4224716 @default.
• W2000891017 hasConcept C529295009 @default.
• W2000891017 hasConcept C55493867 @default.
• W2000891017 hasConcept C71924100 @default.
• W2000891017 hasConcept C74864618 @default.
• W2000891017 hasConcept C86803240 @default.
• W2000891017 hasConcept C90924648 @default.
• W2000891017 hasConceptScore W2000891017C126322002 @default.
• W2000891017 hasConceptScore W2000891017C131253125 @default.
• W2000891017 hasConceptScore W2000891017C142724271 @default.
• W2000891017 hasConceptScore W2000891017C181199279 @default.
• W2000891017 hasConceptScore W2000891017C204232928 @default.
• W2000891017 hasConceptScore W2000891017C2776409635 @default.
• W2000891017 hasConceptScore W2000891017C2776914184 @default.
• W2000891017 hasConceptScore W2000891017C2777310793 @default.
• W2000891017 hasConceptScore W2000891017C2778677798 @default.
• W2000891017 hasConceptScore W2000891017C2779422922 @default.
• W2000891017 hasConceptScore W2000891017C2779689624 @default.
• W2000891017 hasConceptScore W2000891017C2780561475 @default.
• W2000891017 hasConceptScore W2000891017C2781443798 @default.
• W2000891017 hasConceptScore W2000891017C4224716 @default.
• W2000891017 hasConceptScore W2000891017C529295009 @default.
• W2000891017 hasConceptScore W2000891017C55493867 @default.
• W2000891017 hasConceptScore W2000891017C71924100 @default.
• W2000891017 hasConceptScore W2000891017C74864618 @default.
• W2000891017 hasConceptScore W2000891017C86803240 @default.
• W2000891017 hasConceptScore W2000891017C90924648 @default.
• W2000891017 hasIssue "5" @default.
• W2000891017 hasLocation W20008910171 @default.
• W2000891017 hasLocation W20008910172 @default.
• W2000891017 hasLocation W20008910173 @default.
• W2000891017 hasLocation W20008910174 @default.
• W2000891017 hasOpenAccess W2000891017 @default.
• W2000891017 hasPrimaryLocation W20008910171 @default.
• W2000891017 hasRelatedWork W1986464133 @default.
• W2000891017 hasRelatedWork W2022104641 @default.
• W2000891017 hasRelatedWork W2022380145 @default.
• W2000891017 hasRelatedWork W2033683813 @default.
• W2000891017 hasRelatedWork W2041118438 @default.
• W2000891017 hasRelatedWork W2083984374 @default.
• W2000891017 hasRelatedWork W2441468454 @default.
• W2000891017 hasRelatedWork W2992154805 @default.
• W2000891017 hasRelatedWork W2993652586 @default.
• W2000891017 hasRelatedWork W301857740 @default.
• W2000891017 hasVolume "94" @default.
• W2000891017 isParatext "false" @default.
• W2000891017 isRetracted "false" @default.
• W2000891017 magId "2000891017" @default.

• next