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• W2000893276 abstract "It is known that connective tissue-active peptides (CTAP) are released at sites of inflammation. Some of this material diffuses to immediately adjacent tissue and increases ground substance viscosity and fibroblast proliferation. This contributes to host protection against spread of infections and tumors. In a person with normal inflammatory reactivity, it should prevent spread of mediators and products of local inflammation. However, the host with an increased reactivity in sites of increased ground substance viscosity or who is highly reactive to dilution of tissue fluid would respond with more inflammation. A non-infectious, non-malignant process in a host with a highly reactive inflammatory or immune response could end up with peripheral spread. This could occur in any tissue but it occurs with great vigor in the skin. It could present as a peripheral extension of a local disease process, such as psoriasis, or the migration of cyclic lesions with clearing of the central area. There are over a dozen variants of peripherally spreading, ringed lesions described in the dermatologic literature. This includes erythema marginatum of rheumatic fever, erythema gyratum repens associated with cancer, and erythema annulare centrificum associated with allergic reactions to fungi. Many of the ringed dermatologic lesions have an immunologic component. They tend to be associated with inflammatory immune reactions at distant sites. Dermatologists have been gathering information on the ringed phenomenon at least since Hebra in 1854. The acute localized ground substance adaptive phenomenon is a broadly beneficial biologic response. It is essentially the same process as walling off an infection but it is also important in localizing inflammation at times and causing peripheral extension at other times. There is a large number of substances released in acute inflammation, immune reactions, and tissue reactions. The explanation given for increased viscosity is probably an over simplification but the general phenomenon of localized increased ground substance viscosity is very likely to exist." @default.
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• W2000893276 date "1989-07-01" @default.
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• W2000893276 title "A mechanism of peripheral spread or localization of inflammatory reactions — Role of the localized ground substance adaptive phenomenon" @default.
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• W2000893276 doi "https://doi.org/10.1016/0306-9877(89)90189-8" @default.
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