FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000893487> ?p ?o ?g. }

• W2000893487 endingPage "98" @default.
• W2000893487 startingPage "92" @default.
• W2000893487 abstract "G protein-coupled receptors (GPCRs) play critical physiological and therapeutic roles. The human cannabinoid 1 GPCR (hCB1) is a prime pharmacotherapeutic target for addiction and cardiometabolic disease. Our prior biophysical studies on the structural biology of a synthetic peptide representing the functionally significant hCB1 transmembrane helix 7 (TMH7) and its cytoplasmic extension, helix 8 (H8), [hCB1(TMH7/H8)] demonstrated that the helices are oriented virtually perpendicular to each other in membrane-mimetic environments. We identified several hCB1(TMH7/H8) structure-function determinants, including multiple electrostatic amino-acid interactions and a proline kink involving the highly conserved NPXXY motif. In phospholipid bicelles, TMH7 structure, orientation, and topology relative to H8 are dynamically modulated by the surrounding membrane phospholipid bilayer. These data provide a contextual basis for the present solid-state NMR study to investigate whether intermolecular interactions between hCB1(TMH7/H8) and its phospholipid environment may affect membrane-bilayer structure. For this purpose, we measured 1H–13C heteronuclear dipolar couplings for the choline, glycerol, and acyl-chain regions of dimyristoylphosphocholine in a magnetically aligned hCB1(TMH7/H8) bicelle sample. The results identify discrete regional interactions between hCB1(TMH7/H8) and membrane lipid molecules that increase phospholipid motion and decrease phospholipid order, indicating that the peptide’s partial traversal of the bilayer alters membrane structure. These data offer new insight into hCB1(TMH7/H8) properties and support the concept that the membrane bilayer itself may serve as a mechanochemical mediator of hCB1/GPCR signal transduction. Since interaction with its membrane environment has been implicated in hCB1 function and its modulation by small-molecule therapeutics, our work should help inform hCB1 pharmacology and the design of hCB1-targeted drugs." @default.
• W2000893487 created "2016-06-24" @default.
• W2000893487 creator A5000540926 @default.
• W2000893487 creator A5011293469 @default.
• W2000893487 creator A5042428722 @default.
• W2000893487 creator A5045369109 @default.
• W2000893487 creator A5052404618 @default.
• W2000893487 creator A5075195709 @default.
• W2000893487 date "2011-01-14" @default.
• W2000893487 modified "2023-10-14" @default.
• W2000893487 title "Human Cannabinoid 1 GPCR C-Terminal Domain Interacts with Bilayer Phospholipids to Modulate the Structure of its Membrane Environment" @default.
• W2000893487 cites W1482715024 @default.
• W2000893487 cites W1605952717 @default.
• W2000893487 cites W1825353903 @default.
• W2000893487 cites W1963776748 @default.
• W2000893487 cites W1964832767 @default.
• W2000893487 cites W1966869152 @default.
• W2000893487 cites W1967930295 @default.
• W2000893487 cites W1968001320 @default.
• W2000893487 cites W1974536141 @default.
• W2000893487 cites W1975740938 @default.
• W2000893487 cites W1978296715 @default.
• W2000893487 cites W1988097700 @default.
• W2000893487 cites W1989971979 @default.
• W2000893487 cites W1990515637 @default.
• W2000893487 cites W1993677150 @default.
• W2000893487 cites W1993846667 @default.
• W2000893487 cites W1993865906 @default.
• W2000893487 cites W1996767169 @default.
• W2000893487 cites W2008383753 @default.
• W2000893487 cites W2013962031 @default.
• W2000893487 cites W2021320024 @default.
• W2000893487 cites W2022848673 @default.
• W2000893487 cites W2031282085 @default.
• W2000893487 cites W2041566506 @default.
• W2000893487 cites W2042905058 @default.
• W2000893487 cites W2048949875 @default.
• W2000893487 cites W2052537042 @default.
• W2000893487 cites W2055296995 @default.
• W2000893487 cites W2057392382 @default.
• W2000893487 cites W2058258523 @default.
• W2000893487 cites W2061134762 @default.
• W2000893487 cites W2067867467 @default.
• W2000893487 cites W2074473138 @default.
• W2000893487 cites W2084497006 @default.
• W2000893487 cites W2084963592 @default.
• W2000893487 cites W2085520160 @default.
• W2000893487 cites W2098147858 @default.
• W2000893487 cites W2100406200 @default.
• W2000893487 cites W2104477830 @default.
• W2000893487 cites W2107460409 @default.
• W2000893487 cites W2110810808 @default.
• W2000893487 cites W2113071839 @default.
• W2000893487 cites W2115351521 @default.
• W2000893487 cites W2119552351 @default.
• W2000893487 cites W2127654342 @default.
• W2000893487 cites W2133538301 @default.
• W2000893487 cites W2137422967 @default.
• W2000893487 cites W2149963584 @default.
• W2000893487 cites W2166501811 @default.
• W2000893487 cites W4234412100 @default.
• W2000893487 doi "https://doi.org/10.1208/s12248-010-9244-7" @default.
• W2000893487 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3032089" @default.
• W2000893487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21234731" @default.
• W2000893487 hasPublicationYear "2011" @default.
• W2000893487 type Work @default.
• W2000893487 sameAs 2000893487 @default.
• W2000893487 citedByCount "19" @default.
• W2000893487 countsByYear W20008934872012 @default.
• W2000893487 countsByYear W20008934872013 @default.
• W2000893487 countsByYear W20008934872014 @default.
• W2000893487 countsByYear W20008934872016 @default.
• W2000893487 countsByYear W20008934872017 @default.
• W2000893487 countsByYear W20008934872018 @default.
• W2000893487 countsByYear W20008934872020 @default.
• W2000893487 crossrefType "journal-article" @default.
• W2000893487 hasAuthorship W2000893487A5000540926 @default.
• W2000893487 hasAuthorship W2000893487A5011293469 @default.
• W2000893487 hasAuthorship W2000893487A5042428722 @default.
• W2000893487 hasAuthorship W2000893487A5045369109 @default.
• W2000893487 hasAuthorship W2000893487A5052404618 @default.
• W2000893487 hasAuthorship W2000893487A5075195709 @default.
• W2000893487 hasBestOaLocation W20008934872 @default.
• W2000893487 hasConcept C118892022 @default.
• W2000893487 hasConcept C125501631 @default.
• W2000893487 hasConcept C12554922 @default.
• W2000893487 hasConcept C135285700 @default.
• W2000893487 hasConcept C185592680 @default.
• W2000893487 hasConcept C192157962 @default.
• W2000893487 hasConcept C2778918659 @default.
• W2000893487 hasConcept C39944091 @default.
• W2000893487 hasConcept C41625074 @default.
• W2000893487 hasConcept C55493867 @default.
• W2000893487 hasConcept C62478195 @default.
• W2000893487 hasConcept C63491327 @default.
• W2000893487 hasConcept C76564549 @default.
• W2000893487 hasConcept C86803240 @default.
• W2000893487 hasConceptScore W2000893487C118892022 @default.

• next