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- W2000893573 abstract "Psoriasis is a common, chronic, cell-mediated, inflammatory skin disease. Treatment limitations and a developing understanding of its pathogenesis on a molecular level have encouraged much interest in the field of immunomodulatory therapy.To evaluate the efficacy and safety of fumaric acid esters, in particular dimethylfumarate (DMF), in the treatment of moderate to severe plaque psoriasis intolerant and/or resistant to other conventional systemic therapies.A total of 40 patients were enrolled in this study. DMF was orally administered at the daily dose of 30 mg up to 360 mg for a minimum of 6 months treatment. Patients were followed-up with psoriasis area and severity index (PASI) score assessment, and clinical and photographic documentation.A total of 33 (82.5%) patients achieved complete clinical remission with DMF treatment: eight after 3 months and 25 after 6 months. Adverse events, such as intolerable abdominal cramps and incoercible diarrhoea, occurred in four patients who, for this reason, interrupted therapy.The findings suggest that DMF is a safe, effective and well-tolerated long-term oral treatment worthy of consideration for selective patients." @default.
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- W2000893573 date "2004-01-01" @default.
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- W2000893573 title "Fumaric acid esters in the treatment of psoriasis: an Italian experience" @default.
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- W2000893573 doi "https://doi.org/10.1080/09546630310019346" @default.
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