Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000893933> ?p ?o ?g. }
- W2000893933 endingPage "728" @default.
- W2000893933 startingPage "721" @default.
- W2000893933 abstract "There is evidence of activation of both blood coagulation and platelets in sickle cell disease. For example, plasma samples obtained in the steady state and during painful crisis demonstrate high levels of thrombin generation, depletion of anticoagulant proteins, and abnormal activation of the fibrinolytic system. Similarly, exposure of surface markers such as CD62P and CD40L, along with increased circulating levels of thrombospondin, signal platelet activation. In addition to its effects on the cleavage of fibrinogen and its ability to activate platelets, the increase in circulating thrombin levels, with its wide-ranging effects on endothelial cells and blood vessels, may be important in the pathophysiology of sickle cell disease. Therefore, treatments that could decrease thrombin generation or platelet activation may be beneficial in both the treatment of sickle cell disease and the prevention of complications that characterize this genetic disorder. This review discusses hypercoagulability in the various forms of sickle cell disease, including homozygous sickle cell anemia, hemoglobin SC disease, hemoglobin SD disease, and sickle cell–β-thalassemia." @default.
- W2000893933 created "2016-06-24" @default.
- W2000893933 creator A5036275173 @default.
- W2000893933 creator A5046199747 @default.
- W2000893933 date "2003-12-01" @default.
- W2000893933 modified "2023-10-16" @default.
- W2000893933 title "Hypercoagulability in sickle cell disease: a curious paradox" @default.
- W2000893933 cites W105021832 @default.
- W2000893933 cites W1486313261 @default.
- W2000893933 cites W1544423724 @default.
- W2000893933 cites W1580615597 @default.
- W2000893933 cites W173963036 @default.
- W2000893933 cites W176130659 @default.
- W2000893933 cites W1870573284 @default.
- W2000893933 cites W1964707876 @default.
- W2000893933 cites W1969118882 @default.
- W2000893933 cites W1969182008 @default.
- W2000893933 cites W1971541258 @default.
- W2000893933 cites W1973762235 @default.
- W2000893933 cites W1977320652 @default.
- W2000893933 cites W1977667272 @default.
- W2000893933 cites W1979233174 @default.
- W2000893933 cites W1980107751 @default.
- W2000893933 cites W1980590906 @default.
- W2000893933 cites W1981361161 @default.
- W2000893933 cites W1983168377 @default.
- W2000893933 cites W1984230780 @default.
- W2000893933 cites W1985557909 @default.
- W2000893933 cites W1987089583 @default.
- W2000893933 cites W1988281312 @default.
- W2000893933 cites W1988659749 @default.
- W2000893933 cites W1989254461 @default.
- W2000893933 cites W1989546461 @default.
- W2000893933 cites W1990033742 @default.
- W2000893933 cites W1990926485 @default.
- W2000893933 cites W1993373052 @default.
- W2000893933 cites W1993539946 @default.
- W2000893933 cites W2005214515 @default.
- W2000893933 cites W2005712358 @default.
- W2000893933 cites W2014341094 @default.
- W2000893933 cites W2014826463 @default.
- W2000893933 cites W2015952047 @default.
- W2000893933 cites W2016226738 @default.
- W2000893933 cites W2023234379 @default.
- W2000893933 cites W2030059703 @default.
- W2000893933 cites W2032683322 @default.
- W2000893933 cites W2038661581 @default.
- W2000893933 cites W2039818177 @default.
- W2000893933 cites W2041882614 @default.
- W2000893933 cites W2042071222 @default.
- W2000893933 cites W2046304534 @default.
- W2000893933 cites W2050985847 @default.
- W2000893933 cites W2052784841 @default.
- W2000893933 cites W2053119666 @default.
- W2000893933 cites W2060554108 @default.
- W2000893933 cites W2060759428 @default.
- W2000893933 cites W2062828619 @default.
- W2000893933 cites W2063416975 @default.
- W2000893933 cites W2064598070 @default.
- W2000893933 cites W2064693159 @default.
- W2000893933 cites W2070703767 @default.
- W2000893933 cites W2075160422 @default.
- W2000893933 cites W2079623626 @default.
- W2000893933 cites W2080125656 @default.
- W2000893933 cites W2081572339 @default.
- W2000893933 cites W2082804122 @default.
- W2000893933 cites W2083399493 @default.
- W2000893933 cites W2086227829 @default.
- W2000893933 cites W2087967139 @default.
- W2000893933 cites W2090088395 @default.
- W2000893933 cites W2095095750 @default.
- W2000893933 cites W2108576049 @default.
- W2000893933 cites W2112813064 @default.
- W2000893933 cites W2119888538 @default.
- W2000893933 cites W2123458472 @default.
- W2000893933 cites W2142915976 @default.
- W2000893933 cites W2144776586 @default.
- W2000893933 cites W2152201480 @default.
- W2000893933 cites W2242355950 @default.
- W2000893933 cites W2313541759 @default.
- W2000893933 cites W2409476257 @default.
- W2000893933 cites W2411846615 @default.
- W2000893933 cites W4231307067 @default.
- W2000893933 cites W4239121499 @default.
- W2000893933 cites W4250549871 @default.
- W2000893933 cites W4324263026 @default.
- W2000893933 cites W76506168 @default.
- W2000893933 doi "https://doi.org/10.1016/j.amjmed.2003.07.011" @default.
- W2000893933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14693325" @default.
- W2000893933 hasPublicationYear "2003" @default.
- W2000893933 type Work @default.
- W2000893933 sameAs 2000893933 @default.
- W2000893933 citedByCount "181" @default.
- W2000893933 countsByYear W20008939332012 @default.
- W2000893933 countsByYear W20008939332013 @default.
- W2000893933 countsByYear W20008939332014 @default.
- W2000893933 countsByYear W20008939332015 @default.
- W2000893933 countsByYear W20008939332016 @default.