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• W2000893970 abstract "Urotensin II, through its interaction with its UT receptor, is a potent vasoactive peptide in humans and in several animal models. Recent studies have demonstrated elevated plasma U-II levels in patients with atherosclerosis and coronary artery disease. U-II is expressed in endothelial cells, smooth muscle cells and infiltrating macrophages of atherosclerotic human coronary arteries. UT receptor expression is up-regulated by inflammatory stimuli. Activation of UT receptor by U-II stimulates endothelial and smooth muscle cell proliferation and monocytes chemotaxis. Therefore, in addition to its primary vasoactive effect, these observations suggest a role of U-II and UT receptor in the initiation and/or progression of atherosclerosis." @default.
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• W2000893970 date "2008-05-01" @default.
• W2000893970 modified "2023-10-17" @default.
• W2000893970 title "Urotensin II and atherosclerosis" @default.
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• W2000893970 doi "https://doi.org/10.1016/j.peptides.2007.08.024" @default.
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