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- W2000894694 abstract "Venlafaxine, as a substrate of p-glycoprotein, is a widely used serotonin-noradrenaline reuptake inhibitor (SNRI). The aim of the study is to investigate the influence of ABCB1 G2677T/A, C3435T polymorphisms on efficacy of venlafaxine. Patients (n = 52) who met the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition-IV criteria for major depressive disorder (MDD) were enrolled the study. All patients had affirmed for once a day administration of venlafaxine at 8:00 to 9:00 am during the study. Protocol visits were completed at baseline, 1st, 2nd, 4th, and 6th weeks. The clinical response to venlafaxine was evaluated by psychiatrists with 17-item Hamilton Rating Scale for Depression (HAM-D17). Blood samples were taken for genotyping at 4th week of the study. Genotyping for the ABCB1 gene 3435C>T and G2677T/A polymorphisms was performed by PCR/RFLP assays. Our results showed that there is no correlation between efficacy and tolerability of venlafaxine and ABCB1 G2677T/A, C3435T polymorphisms. But carriers of the TT genotype for 3435C>T polymorphism and carriers of the TT/TA genotype for G2677T/A polymorphism could be tended to be poor responder (Table).TableHAMD17 scores according to ABCB1 G2677T/A, C3435T genotypes.3435C>T2677G>T/ACC-CTTTGG-GT-GATT-TAn41114111HAMD17, baseline21.56 ± 0.69522.45 ± 2.07721.78 ± 0.73721.64 ± 1.865HAMD17,1st week14.93 ± 0.85116.73 ± 2.19515.34 ± 0.85215.18 ± 2.252HAMD17,2nd week13.76 ±0.93915.64 ± 1.82013.59 ± 0.90716.27 ± 1.978HAMD17,4th week11.27 ± 0.96811.54 ± 1.88311.24 ± 0.93112.36 ± 2.125HAMD17,6th week9.63 ± 1.1110.09 ± 2.0959.54 ± 1.03810.45 ± 2.577F = 0.41, P = 0.741F = 0.672, P = 0.563 Open table in a new tab Although our results showed that there is no correlation between efficacy of venlafaxine and ABCB1 G2677T/A, C3435T polymorphisms, we couldn’t reach the sufficient patient number. There is need for studies with sufficient patient number and haplotype analysis including also ABCB1 C1236T polymorphism in MDD patients." @default.
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- W2000894694 date "2013-08-01" @default.
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- W2000894694 title "PP153—Evaluation of the Relationships Between ABCB1 C3435T and G2677T/A Polymorphisms and Clinical Response to Venlafaxine in Patients with Major Depressive Disorder" @default.
- W2000894694 doi "https://doi.org/10.1016/j.clinthera.2013.07.194" @default.
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