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- W2000894772 abstract "Mast cells generated from Rac2-deficient (−/−) mice demonstrated defective actin-based functions, including adhesion, migration, and degranulation. Rac2−/− mast cells generated lower numbers and less mast cell colonies in response to growth factors and were deficient in vivo. Rac2−/− mast cells demonstrated a significant reduction in growth factor–induced survival, which correlated with the lack of activation of Akt and significant changes in the expression of the Bcl-2 family members BAD and Bcl-XL, in spite of a 3-fold induction of Rac1 protein. These results suggest that Rac2 plays a unique role in multiple cellular functions and describe an essential role for Rac2 in growth factor–dependent survival and expression of BAD/Bcl-XL." @default.
- W2000894772 created "2016-06-24" @default.
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- W2000894772 date "2000-05-01" @default.
- W2000894772 modified "2023-10-12" @default.
- W2000894772 title "Rac2 Stimulates Akt Activation Affecting BAD/Bcl-XL Expression while Mediating Survival and Actin Function in Primary Mast Cells" @default.
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- W2000894772 doi "https://doi.org/10.1016/s1074-7613(00)80207-1" @default.
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