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• W2000894855 abstract "Cdc7 expression repressor (CR)/periphilin has been originally cloned as an interactor with periplakin, a precursor of the cornified cell envelope, and suggested to constitute a new type of nuclear matrix. We here show that CR/periphilin is a ubiquitously expressed nuclear protein with speckled distribution. Overexpression of CR/periphilin induces S-phase arrest. Analysis of expression of regulators involved in DNA replication has revealed that both mRNA and protein expression of Cdc7, a regulator of the initiation and continuation of DNA replication, are markedly downregulated by overexpression of CR/periphilin. However, co-expression of Cdc7 only marginally rescues S-phase arrest induced by CR, indicating that CR retards S-phase progression by modifying expression of some genes including Cdc7, which are involved in progression of DNA replication or coordination of DNA replication and S-phase progression." @default.
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• W2000894855 date "2004-11-01" @default.
• W2000894855 modified "2023-10-16" @default.
• W2000894855 title "Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest" @default.
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• W2000894855 doi "https://doi.org/10.1016/j.bbrc.2004.09.083" @default.
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