Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000894883> ?p ?o ?g. }
- W2000894883 endingPage "242" @default.
- W2000894883 startingPage "229" @default.
- W2000894883 abstract "To initiate a genetic analysis of olfactory development and function in the zebrafish, Danio rerio, we developed a behavioral genetic screen for mutations affecting the olfactory sensory system. First, we characterized olfactory responses of wild-type zebrafish to various odors. We found that 3-day-old juvenile zebrafish reacted to the amino acid L-cysteine with an aversive behavioral response. We isolated one mutant, laure (lre), which showed no aversive behavioral response to L-cysteine at 3 days of development, and carried out a preliminary characterization of this mutant's defects. We found that lre mutant fish were also defective in their response to L-serine and L-alanine, but not to taurocholic acid, as young adults. In addition, lre mutant fish had significantly fewer primary olfactory sensory neurons than normal, and the axons of these neurons did not form the characteristic axon termination pattern in the developing olfactory bulb. Nevertheless, the olfactory epithelium of lre mutant fish showed normal or near normal electrophysiological responses to several odorants. Our data suggest that the behavioral defects observed in the lre mutant result from the disruption of the developing olfactory sensory neurons and their axonal connections within the olfactory bulb. The isolation of the lre mutant shows that our behavior-based screen represents a viable approach for carrying out a genetic dissection of olfactory behaviors in this vertebrate model system." @default.
- W2000894883 created "2016-06-24" @default.
- W2000894883 creator A5032593781 @default.
- W2000894883 creator A5042104937 @default.
- W2000894883 creator A5043710192 @default.
- W2000894883 creator A5046017854 @default.
- W2000894883 creator A5081957682 @default.
- W2000894883 date "2005-08-05" @default.
- W2000894883 modified "2023-10-17" @default.
- W2000894883 title "Isolation and characterization of thelaure olfactory behavioral mutant in the zebrafish,Danio rerio" @default.
- W2000894883 cites W112287850 @default.
- W2000894883 cites W1528612804 @default.
- W2000894883 cites W1576096673 @default.
- W2000894883 cites W1585587409 @default.
- W2000894883 cites W1592275382 @default.
- W2000894883 cites W1598780096 @default.
- W2000894883 cites W1737443389 @default.
- W2000894883 cites W1755867506 @default.
- W2000894883 cites W1827818423 @default.
- W2000894883 cites W1932232911 @default.
- W2000894883 cites W1947859348 @default.
- W2000894883 cites W1965333324 @default.
- W2000894883 cites W1966740626 @default.
- W2000894883 cites W1968903374 @default.
- W2000894883 cites W1980029124 @default.
- W2000894883 cites W1983319708 @default.
- W2000894883 cites W1992673078 @default.
- W2000894883 cites W1993683899 @default.
- W2000894883 cites W1995651633 @default.
- W2000894883 cites W2003555882 @default.
- W2000894883 cites W2003717217 @default.
- W2000894883 cites W2004035417 @default.
- W2000894883 cites W2007779343 @default.
- W2000894883 cites W2009262291 @default.
- W2000894883 cites W2009288308 @default.
- W2000894883 cites W2017236121 @default.
- W2000894883 cites W2018258016 @default.
- W2000894883 cites W2018980625 @default.
- W2000894883 cites W2021950534 @default.
- W2000894883 cites W2022790467 @default.
- W2000894883 cites W2025142458 @default.
- W2000894883 cites W2029185976 @default.
- W2000894883 cites W2029459747 @default.
- W2000894883 cites W2046144675 @default.
- W2000894883 cites W2049811286 @default.
- W2000894883 cites W2050019535 @default.
- W2000894883 cites W2060063624 @default.
- W2000894883 cites W2060776642 @default.
- W2000894883 cites W2061640623 @default.
- W2000894883 cites W2062728419 @default.
- W2000894883 cites W2063234657 @default.
- W2000894883 cites W2065274926 @default.
- W2000894883 cites W2066682414 @default.
- W2000894883 cites W2069062595 @default.
- W2000894883 cites W2070957386 @default.
- W2000894883 cites W2074316017 @default.
- W2000894883 cites W2078841219 @default.
- W2000894883 cites W2079755276 @default.
- W2000894883 cites W2080472416 @default.
- W2000894883 cites W2081399343 @default.
- W2000894883 cites W2081449377 @default.
- W2000894883 cites W2087555448 @default.
- W2000894883 cites W2097186487 @default.
- W2000894883 cites W2101458355 @default.
- W2000894883 cites W2123938765 @default.
- W2000894883 cites W2125349610 @default.
- W2000894883 cites W2130609073 @default.
- W2000894883 cites W2132800912 @default.
- W2000894883 cites W2134747272 @default.
- W2000894883 cites W2138742825 @default.
- W2000894883 cites W2148211715 @default.
- W2000894883 cites W2158893862 @default.
- W2000894883 cites W2182268835 @default.
- W2000894883 cites W2184072796 @default.
- W2000894883 cites W2411058364 @default.
- W2000894883 cites W4240053492 @default.
- W2000894883 doi "https://doi.org/10.1002/dvdy.20530" @default.
- W2000894883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16086331" @default.
- W2000894883 hasPublicationYear "2005" @default.
- W2000894883 type Work @default.
- W2000894883 sameAs 2000894883 @default.
- W2000894883 citedByCount "62" @default.
- W2000894883 countsByYear W20008948832012 @default.
- W2000894883 countsByYear W20008948832013 @default.
- W2000894883 countsByYear W20008948832014 @default.
- W2000894883 countsByYear W20008948832015 @default.
- W2000894883 countsByYear W20008948832016 @default.
- W2000894883 countsByYear W20008948832017 @default.
- W2000894883 countsByYear W20008948832018 @default.
- W2000894883 countsByYear W20008948832019 @default.
- W2000894883 countsByYear W20008948832020 @default.
- W2000894883 countsByYear W20008948832021 @default.
- W2000894883 countsByYear W20008948832022 @default.
- W2000894883 crossrefType "journal-article" @default.
- W2000894883 hasAuthorship W2000894883A5032593781 @default.
- W2000894883 hasAuthorship W2000894883A5042104937 @default.
- W2000894883 hasAuthorship W2000894883A5043710192 @default.
- W2000894883 hasAuthorship W2000894883A5046017854 @default.