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- W2000895093 abstract "Factors that determine the differential expression of isoforms of Na(+),K(+)-ATPase in the nervous system of vertebrates are not understood. To address this question we studied the expression of alpha(3) Na(+),K(+)-ATPase in the L5 dorsal root ganglia (DRG) of developing rat, the normal adult rat, and the adult rat after peripheral axotomy. During development, the first alpha(3) Na(+),K(+)-ATPase-positive DRG neurons appear by embryonic day 21. At birth, the L5 DRG have a full complement (14 +/- 2%) of these neurons. By 15 days after sciatic nerve transection in adult rat, the number of alpha(3) Na(+),K(+)-ATPase-positive DRG neurons and small myelinated L5 ventral root axons decreases to about 35% of control counts. These results combined with data from the literature suggest that the expression of alpha(3) Na(+),K(+)-ATPase by rat somatic neurons is determined by target-muscle spindle-derived factors." @default.
- W2000895093 created "2016-06-24" @default.
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- W2000895093 date "2005-01-01" @default.
- W2000895093 modified "2023-10-13" @default.
- W2000895093 title "Target-determined expression of ?3 isoform of the Na+,K+-ATPase in the somatic nervous system of rat" @default.
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- W2000895093 doi "https://doi.org/10.1002/cne.20401" @default.
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