Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000895812> ?p ?o ?g. }
- W2000895812 endingPage "269" @default.
- W2000895812 startingPage "256" @default.
- W2000895812 abstract "Laminin-5 is an important basement membrane protein that regulates cell adhesion and motility. It was previously found that the γ2 chain of laminin-5 is transiently expressed in embryonic cartilage. This suggests a possible role of laminin-5 in chondrogenesis. Here, we examined this possibility using the murine teratocarcinoma cell line ATDC5. ATDC5 cells transiently and weakly expressed laminin-5 when they were stimulated for differentiation. Exogenous laminin-5 in either insoluble or soluble form strongly inhibited the differentiation phenotypes, i.e. formation of cartilaginous cell aggregates and production of chondrogenic marker proteins through its integrin-binding domain LG3 in the α3 chain. Laminin-5 had no effect on cell growth. In addition, we found that the laminin-5 with the 105-kDa, processed γ2 chain suppressed differentiation more strongly than one with the 150-kDa γ2 chain. This indicated that the proteolytic processing of γ2 chain regulated the activity of laminin-5. However, a γ2 chain short arm fragment had no effect on the chondrogenesis, and it rather suppressed the differentiation at excessive concentrations. These results suggest that laminin-5 and its processing modulate chondrogenic differentiation during development." @default.
- W2000895812 created "2016-06-24" @default.
- W2000895812 creator A5009882274 @default.
- W2000895812 creator A5036144743 @default.
- W2000895812 creator A5055570113 @default.
- W2000895812 creator A5089516155 @default.
- W2000895812 date "2005-11-01" @default.
- W2000895812 modified "2023-10-17" @default.
- W2000895812 title "Laminin-5 suppresses chondrogenic differentiation of murine teratocarcinoma cell line ATDC5" @default.
- W2000895812 cites W1496915816 @default.
- W2000895812 cites W1510094212 @default.
- W2000895812 cites W1767393153 @default.
- W2000895812 cites W1839350769 @default.
- W2000895812 cites W1967269017 @default.
- W2000895812 cites W1968084778 @default.
- W2000895812 cites W1972682554 @default.
- W2000895812 cites W1978327680 @default.
- W2000895812 cites W1978410998 @default.
- W2000895812 cites W1978837916 @default.
- W2000895812 cites W1982292830 @default.
- W2000895812 cites W1982372868 @default.
- W2000895812 cites W1983448619 @default.
- W2000895812 cites W1985491088 @default.
- W2000895812 cites W1990084142 @default.
- W2000895812 cites W1992953131 @default.
- W2000895812 cites W2000327471 @default.
- W2000895812 cites W2001226357 @default.
- W2000895812 cites W2002453151 @default.
- W2000895812 cites W2009568983 @default.
- W2000895812 cites W2009598071 @default.
- W2000895812 cites W2010463041 @default.
- W2000895812 cites W2011205303 @default.
- W2000895812 cites W2012491088 @default.
- W2000895812 cites W2022447514 @default.
- W2000895812 cites W2025361420 @default.
- W2000895812 cites W2027254518 @default.
- W2000895812 cites W2032372303 @default.
- W2000895812 cites W2032879380 @default.
- W2000895812 cites W2037761995 @default.
- W2000895812 cites W2042932723 @default.
- W2000895812 cites W2043983708 @default.
- W2000895812 cites W2050273631 @default.
- W2000895812 cites W2063128557 @default.
- W2000895812 cites W2067693141 @default.
- W2000895812 cites W2075965099 @default.
- W2000895812 cites W2077061694 @default.
- W2000895812 cites W2087183300 @default.
- W2000895812 cites W2090848574 @default.
- W2000895812 cites W2090892805 @default.
- W2000895812 cites W2091189056 @default.
- W2000895812 cites W2093030407 @default.
- W2000895812 cites W2099264907 @default.
- W2000895812 cites W2117812940 @default.
- W2000895812 cites W2121513486 @default.
- W2000895812 cites W2128681786 @default.
- W2000895812 cites W2142266008 @default.
- W2000895812 cites W2148142890 @default.
- W2000895812 cites W2149718794 @default.
- W2000895812 cites W2152806358 @default.
- W2000895812 cites W2157834399 @default.
- W2000895812 cites W2159999899 @default.
- W2000895812 cites W2161781897 @default.
- W2000895812 cites W2165524164 @default.
- W2000895812 cites W407510365 @default.
- W2000895812 cites W4211112402 @default.
- W2000895812 doi "https://doi.org/10.1016/j.yexcr.2005.07.025" @default.
- W2000895812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16165127" @default.
- W2000895812 hasPublicationYear "2005" @default.
- W2000895812 type Work @default.
- W2000895812 sameAs 2000895812 @default.
- W2000895812 citedByCount "10" @default.
- W2000895812 countsByYear W20008958122012 @default.
- W2000895812 countsByYear W20008958122016 @default.
- W2000895812 countsByYear W20008958122017 @default.
- W2000895812 countsByYear W20008958122018 @default.
- W2000895812 crossrefType "journal-article" @default.
- W2000895812 hasAuthorship W2000895812A5009882274 @default.
- W2000895812 hasAuthorship W2000895812A5036144743 @default.
- W2000895812 hasAuthorship W2000895812A5055570113 @default.
- W2000895812 hasAuthorship W2000895812A5089516155 @default.
- W2000895812 hasConcept C104317684 @default.
- W2000895812 hasConcept C148738053 @default.
- W2000895812 hasConcept C189165786 @default.
- W2000895812 hasConcept C198826908 @default.
- W2000895812 hasConcept C2776193487 @default.
- W2000895812 hasConcept C2779814568 @default.
- W2000895812 hasConcept C2908788973 @default.
- W2000895812 hasConcept C35496256 @default.
- W2000895812 hasConcept C54355233 @default.
- W2000895812 hasConcept C55493867 @default.
- W2000895812 hasConcept C81885089 @default.
- W2000895812 hasConcept C86803240 @default.
- W2000895812 hasConcept C95444343 @default.
- W2000895812 hasConceptScore W2000895812C104317684 @default.
- W2000895812 hasConceptScore W2000895812C148738053 @default.
- W2000895812 hasConceptScore W2000895812C189165786 @default.
- W2000895812 hasConceptScore W2000895812C198826908 @default.
- W2000895812 hasConceptScore W2000895812C2776193487 @default.