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- W2000897500 abstract "Unilateral intrastriatal injection of various substances induces a characteristic dyskinetic syndrome in rats. These substances include picrotoxin as well as a series of irreversible GABA-transaminase inhibitors. Using the degree of enzyme inhibition in various brain areas as a measure of drug distribution following intrastriatal administration of γ-acetylenic GABA and γ-vinyl GABA, there was found considerable retrodiffusion via the needle tract to the overlying cortex. Topical application of γ-acetylenic GABA and γ-vinyl GABA to the cortical surface overlying the striatum produced a high incidence of identical dyskinesias without any evidence of diffusion of drugs to the striatum. The cortically induced movements could be duplicated by picrotoxin application to a defined cortical area. TThese findings suggest that interference with gabaergic function in the striatum is not necessary for the production of the dyskinetic syndrome and that this syndrome may be a cortically induced phenomenon." @default.
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- W2000897500 date "1980-04-01" @default.
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- W2000897500 title "An analysis of the cortical and striatal involvement in dyskinesia induced in rats by intracerebral injection of GABA-transaminase inhibitors and picrotoxin" @default.
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- W2000897500 doi "https://doi.org/10.1016/0014-2999(80)90099-0" @default.
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