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- W2000897528 abstract "The influence of three parameters on the degree of acquired tolerance to ethanol was studied using goldfish as the animal model. These factors were: a) the rate of ethanol administration; b) the repeated performance of the behavioral test, and c) the prior presence of tolerance to a low dose of ethanol. Tolerance, as indicated by the increase in the ethanol brain levels associated with the loss of righting reflex (overturn test), was observed in fish exposed to 0.2, 0.4, or 0.6% (w/v) ethanol for 1 to 24 hours independently of the rate of ethanol administration. Fish exposed to 0.8% (w/v) ethanol developed tolerance only when this ethanol concentration was reached slowly (circa 3 hours). The increase in functional demand by the repeated testing of the fish and the presence of tolerance to a low dose of ethanol (0.4%) did not affect the degree of the observed tolerance in fish left to equilibrate with a 0.8% ethanol dose. The data support the suggestion that motor functions controlled by the central nervous system can adapt to a high concentration of ethanol if an adequate amount of time is allowed for this compensation to occur or if this concentration is reached slowly. Furthermore, in goldfish the degree of acquired tolerance is directly proportional to the concentration of the ethanol during the time of exposure and independent of the previous experience in alcohol solution." @default.
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- W2000897528 date "1977-11-01" @default.
- W2000897528 modified "2023-09-27" @default.
- W2000897528 title "Factors influencing the development of tolerance to ethanol" @default.
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- W2000897528 doi "https://doi.org/10.1016/0024-3205(77)90005-4" @default.
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