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• W2000897557 abstract "It has remained difficult to ascribe a specific functional role to immobile or fixed intracellular calcium buffers in central neurons because the amount of these buffers is unknown. Here, we explicitly isolated the fixed buffer fraction by prolonged whole-cell patch-clamp dialysis and quantified its buffering capacity in murine hippocampal slices using confocal calcium imaging and the added-buffer approach. In dentate granule cells, the calcium binding ratio (κ) after complete washout of calbindin D28k (Cb), κfixed, displayed a substantial value of ∼100. In contrast, in CA1 oriens lacunosum moleculare (OLM) interneurons, which do not contain any known calcium-binding protein(s), κfixed amounted to only ∼30. Based on these values, a theoretical analysis of dendritic spread of calcium after local entry showed that fixed buffers, in the absence of mobile species, decrease intracellular calcium mobility 100- and 30-fold in granule cells and OLM cells, respectively, and thereby strongly slow calcium signals. Although the large κfixed alone strongly delays the spread of calcium in granule cells, this value optimizes the benefits of additionally expressing the mobile calcium binding protein Cb. With such high κfixed, Cb effectively increases the propagation velocity to levels seen in OLM cells and, contrary to expectation, does not affect the peak calcium concentration close to the source but sharpens the spatial and temporal calcium gradients. The data suggest that the amount of fixed buffers determines the temporal availability of calcium for calcium-binding partners and plays a pivotal role in setting the repertoire of cellular calcium signaling regimens." @default.
• W2000897557 created "2016-06-24" @default.
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• W2000897557 date "2013-09-04" @default.
• W2000897557 modified "2023-09-27" @default.
• W2000897557 title "Tuning Local Calcium Availability: Cell-Type-Specific Immobile Calcium Buffer Capacity in Hippocampal Neurons" @default.
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• W2000897557 doi "https://doi.org/10.1523/jneurosci.4118-12.2013" @default.
• W2000897557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6618380" @default.
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