FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000897994> ?p ?o ?g. }

• W2000897994 endingPage "437" @default.
• W2000897994 startingPage "429" @default.
• W2000897994 abstract "When retinal pigmented epithelial cells (PEC) of chick embryos are cultured under appropriate conditions, the phenotype changes to that of lens cells through a process known as transdifferentiation. The first half of the process, characterized by dedifferentiation of PEC, is accompanied by a marked decrease in adhesiveness of PEC to collagen type I- or type IV-coated dishes. To understand the underlying mechanisms of this change, we analyzed the expression of integrins, which are major receptors for extracellular matrix components. Northern blot analysis with cDNA probes for chicken α3, α6, α8, αv, β1 and β5 integrin mRNA showed that the genes for all these integrins are transcribed at similar levels in PEC and dedifferentiated PEC (dePEC). Further analysis of β1 integrin, which is a major component of integrin heterodimers, showed that although the protein amount of β1 integrin was not changed, its localization at focal contacts seen in PEC was lost in dePEC. When anti-β1 integrin antibody was added to the PEC culture medium, a decrease of cell-substrate adhesiveness occurred, followed by a gradual change in both morphology and gene expression patterns to ones similar to those of dePEC. These findings suggest that an appropriate distribution of β1 integrin plays an essential role in maintaining the differentiated state of PEC through cell-substrate adhesion." @default.
• W2000897994 created "2016-06-24" @default.
• W2000897994 creator A5002011358 @default.
• W2000897994 creator A5009455773 @default.
• W2000897994 creator A5047418498 @default.
• W2000897994 creator A5083215699 @default.
• W2000897994 date "1996-08-01" @default.
• W2000897994 modified "2023-09-23" @default.
• W2000897994 title "Role of integrins in differentiation of chick retinal pigmented epithelial cells in vitro" @default.
• W2000897994 cites W1461283487 @default.
• W2000897994 cites W1905978178 @default.
• W2000897994 cites W1939326986 @default.
• W2000897994 cites W1970592275 @default.
• W2000897994 cites W1971019443 @default.
• W2000897994 cites W1984489245 @default.
• W2000897994 cites W1989557131 @default.
• W2000897994 cites W1994106608 @default.
• W2000897994 cites W2014669590 @default.
• W2000897994 cites W2018289835 @default.
• W2000897994 cites W2029231027 @default.
• W2000897994 cites W2034001472 @default.
• W2000897994 cites W2036145275 @default.
• W2000897994 cites W2040215507 @default.
• W2000897994 cites W2040473111 @default.
• W2000897994 cites W2043117244 @default.
• W2000897994 cites W2047423042 @default.
• W2000897994 cites W2050014442 @default.
• W2000897994 cites W2051461114 @default.
• W2000897994 cites W2054779757 @default.
• W2000897994 cites W2057047909 @default.
• W2000897994 cites W2057620760 @default.
• W2000897994 cites W2066367871 @default.
• W2000897994 cites W2070846527 @default.
• W2000897994 cites W2075461794 @default.
• W2000897994 cites W2077077811 @default.
• W2000897994 cites W2088263789 @default.
• W2000897994 cites W2100837269 @default.
• W2000897994 cites W2101108802 @default.
• W2000897994 cites W2148645241 @default.
• W2000897994 cites W2294334808 @default.
• W2000897994 cites W2312776752 @default.
• W2000897994 cites W2339020790 @default.
• W2000897994 cites W2410724050 @default.
• W2000897994 cites W4250894260 @default.
• W2000897994 cites W56387099 @default.
• W2000897994 doi "https://doi.org/10.1046/j.1440-169x.1996.t01-3-00011.x" @default.
• W2000897994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37281463" @default.
• W2000897994 hasPublicationYear "1996" @default.
• W2000897994 type Work @default.
• W2000897994 sameAs 2000897994 @default.
• W2000897994 citedByCount "24" @default.
• W2000897994 crossrefType "journal-article" @default.
• W2000897994 hasAuthorship W2000897994A5002011358 @default.
• W2000897994 hasAuthorship W2000897994A5009455773 @default.
• W2000897994 hasAuthorship W2000897994A5047418498 @default.
• W2000897994 hasAuthorship W2000897994A5083215699 @default.
• W2000897994 hasConcept C104317684 @default.
• W2000897994 hasConcept C1491633281 @default.
• W2000897994 hasConcept C150194340 @default.
• W2000897994 hasConcept C151166631 @default.
• W2000897994 hasConcept C153911025 @default.
• W2000897994 hasConcept C170493617 @default.
• W2000897994 hasConcept C177707886 @default.
• W2000897994 hasConcept C189165786 @default.
• W2000897994 hasConcept C195687474 @default.
• W2000897994 hasConcept C28328180 @default.
• W2000897994 hasConcept C54355233 @default.
• W2000897994 hasConcept C55493867 @default.
• W2000897994 hasConcept C60870556 @default.
• W2000897994 hasConcept C62478195 @default.
• W2000897994 hasConcept C81885089 @default.
• W2000897994 hasConcept C85789140 @default.
• W2000897994 hasConcept C86803240 @default.
• W2000897994 hasConcept C95444343 @default.
• W2000897994 hasConceptScore W2000897994C104317684 @default.
• W2000897994 hasConceptScore W2000897994C1491633281 @default.
• W2000897994 hasConceptScore W2000897994C150194340 @default.
• W2000897994 hasConceptScore W2000897994C151166631 @default.
• W2000897994 hasConceptScore W2000897994C153911025 @default.
• W2000897994 hasConceptScore W2000897994C170493617 @default.
• W2000897994 hasConceptScore W2000897994C177707886 @default.
• W2000897994 hasConceptScore W2000897994C189165786 @default.
• W2000897994 hasConceptScore W2000897994C195687474 @default.
• W2000897994 hasConceptScore W2000897994C28328180 @default.
• W2000897994 hasConceptScore W2000897994C54355233 @default.
• W2000897994 hasConceptScore W2000897994C55493867 @default.
• W2000897994 hasConceptScore W2000897994C60870556 @default.
• W2000897994 hasConceptScore W2000897994C62478195 @default.
• W2000897994 hasConceptScore W2000897994C81885089 @default.
• W2000897994 hasConceptScore W2000897994C85789140 @default.
• W2000897994 hasConceptScore W2000897994C86803240 @default.
• W2000897994 hasConceptScore W2000897994C95444343 @default.
• W2000897994 hasIssue "4" @default.
• W2000897994 hasLocation W20008979941 @default.
• W2000897994 hasLocation W20008979942 @default.
• W2000897994 hasOpenAccess W2000897994 @default.
• W2000897994 hasPrimaryLocation W20008979941 @default.
• W2000897994 hasRelatedWork W1601813195 @default.

• next