FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000900257> ?p ?o ?g. }

• W2000900257 endingPage "2621" @default.
• W2000900257 startingPage "2613" @default.
• W2000900257 abstract "The development of a collateral circulation (arteriogenesis), bypassing an arterial occlusion, is important for tissue survival, but it remains functionally defective. Micro array data of growing collateral vessels, exposed to chronically elevated fluid shear stress (FSS), showed increased transcription of the transient receptor potential cation channel, subfamily V, member 4 (Trpv4). Thus, the aim of this study was to investigate the role of the shear stress sensitive Trpv4 in transmitting this physical stimulus into an active growth response. qRT-PCR at different time points during the growth of collateral vessels after femoral artery ligature (FAL) in rats showed a strong positive correlation of Trpv4 transcription and the intensity of FSS. An increased protein expression of Trpv4 was localized in the FSS-sensing endothelium by means of confocal immunohistochemistry. Cultured porcine endothelial cells showed a dose-dependent expression of Trpv4 and an increased level of Ki67-positive cells upon treatment with 4α-Phorbol 12,13-didecanoate (4αPDD), a specific Trpv4 activator. This was also demonstrated by flow culture experiments. These results were confirmed by in vivo application of 4αPDD in rabbit hind limb circulation via an osmotic mini-pump after FAL. Trpv4 expression as well as Ki67-positive staining was significantly increased in collateral vessels. Finally, 4αPDD treatment after FAL led to a 61% (215.5 ml/min/mmHg versus 350 ml/min/mmHg) recovery of conductance when compared with the non-occluded artery. Cell culture and in vivo studies demonstrate that an FSS- or a 4αPDD-induced activation of Trpv4 leads to an active proliferation of vascular cells and finally triggers collateral growth. Trpv4, a well-known FSS-sensitive vasodilator, has hitherto not been implicated in active growth processes of collateral arteries. This new function may lead to new therapeutic strategies for the treatment of arterial occlusive diseases." @default.
• W2000900257 created "2016-06-24" @default.
• W2000900257 creator A5001576739 @default.
• W2000900257 creator A5013484027 @default.
• W2000900257 creator A5014785819 @default.
• W2000900257 creator A5018791508 @default.
• W2000900257 creator A5037576774 @default.
• W2000900257 creator A5038589044 @default.
• W2000900257 creator A5038941000 @default.
• W2000900257 creator A5051208662 @default.
• W2000900257 creator A5057368267 @default.
• W2000900257 creator A5069282252 @default.
• W2000900257 creator A5076255298 @default.
• W2000900257 creator A5086967376 @default.
• W2000900257 date "2008-11-06" @default.
• W2000900257 modified "2023-10-16" @default.
• W2000900257 title "Trpv4 induces collateral vessel growth during regeneration of the arterial circulation" @default.
• W2000900257 cites W1545384325 @default.
• W2000900257 cites W1964567018 @default.
• W2000900257 cites W1966765895 @default.
• W2000900257 cites W1986615127 @default.
• W2000900257 cites W2002520417 @default.
• W2000900257 cites W2007730384 @default.
• W2000900257 cites W2009089019 @default.
• W2000900257 cites W2013088475 @default.
• W2000900257 cites W2016324413 @default.
• W2000900257 cites W2021367503 @default.
• W2000900257 cites W2049247347 @default.
• W2000900257 cites W2056428937 @default.
• W2000900257 cites W2059379142 @default.
• W2000900257 cites W2072942836 @default.
• W2000900257 cites W2082157250 @default.
• W2000900257 cites W2084415764 @default.
• W2000900257 cites W2100190333 @default.
• W2000900257 cites W2107006878 @default.
• W2000900257 cites W2114908816 @default.
• W2000900257 cites W2118148454 @default.
• W2000900257 cites W2119533880 @default.
• W2000900257 cites W2128576216 @default.
• W2000900257 cites W2137224035 @default.
• W2000900257 cites W2150070295 @default.
• W2000900257 cites W2152982406 @default.
• W2000900257 cites W2155935601 @default.
• W2000900257 cites W2161953383 @default.
• W2000900257 cites W2170874661 @default.
• W2000900257 cites W2171234320 @default.
• W2000900257 cites W2331499429 @default.
• W2000900257 cites W4230830236 @default.
• W2000900257 cites W4299696637 @default.
• W2000900257 doi "https://doi.org/10.1111/j.1582-4934.2008.00579.x" @default.
• W2000900257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6512359" @default.
• W2000900257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19017361" @default.
• W2000900257 hasPublicationYear "2008" @default.
• W2000900257 type Work @default.
• W2000900257 sameAs 2000900257 @default.
• W2000900257 citedByCount "71" @default.
• W2000900257 countsByYear W20009002572012 @default.
• W2000900257 countsByYear W20009002572013 @default.
• W2000900257 countsByYear W20009002572014 @default.
• W2000900257 countsByYear W20009002572015 @default.
• W2000900257 countsByYear W20009002572016 @default.
• W2000900257 countsByYear W20009002572017 @default.
• W2000900257 countsByYear W20009002572018 @default.
• W2000900257 countsByYear W20009002572019 @default.
• W2000900257 countsByYear W20009002572020 @default.
• W2000900257 countsByYear W20009002572021 @default.
• W2000900257 countsByYear W20009002572022 @default.
• W2000900257 countsByYear W20009002572023 @default.
• W2000900257 crossrefType "journal-article" @default.
• W2000900257 hasAuthorship W2000900257A5001576739 @default.
• W2000900257 hasAuthorship W2000900257A5013484027 @default.
• W2000900257 hasAuthorship W2000900257A5014785819 @default.
• W2000900257 hasAuthorship W2000900257A5018791508 @default.
• W2000900257 hasAuthorship W2000900257A5037576774 @default.
• W2000900257 hasAuthorship W2000900257A5038589044 @default.
• W2000900257 hasAuthorship W2000900257A5038941000 @default.
• W2000900257 hasAuthorship W2000900257A5051208662 @default.
• W2000900257 hasAuthorship W2000900257A5057368267 @default.
• W2000900257 hasAuthorship W2000900257A5069282252 @default.
• W2000900257 hasAuthorship W2000900257A5076255298 @default.
• W2000900257 hasAuthorship W2000900257A5086967376 @default.
• W2000900257 hasBestOaLocation W20009002571 @default.
• W2000900257 hasConcept C105702510 @default.
• W2000900257 hasConcept C126322002 @default.
• W2000900257 hasConcept C150903083 @default.
• W2000900257 hasConcept C170493617 @default.
• W2000900257 hasConcept C185592680 @default.
• W2000900257 hasConcept C207001950 @default.
• W2000900257 hasConcept C2776599846 @default.
• W2000900257 hasConcept C2777408375 @default.
• W2000900257 hasConcept C2780394083 @default.
• W2000900257 hasConcept C50254741 @default.
• W2000900257 hasConcept C55493867 @default.
• W2000900257 hasConcept C71924100 @default.
• W2000900257 hasConcept C86803240 @default.
• W2000900257 hasConcept C90420996 @default.
• W2000900257 hasConcept C95444343 @default.
• W2000900257 hasConceptScore W2000900257C105702510 @default.

• next