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- W2000901542 abstract "TMEM106B variants are genetically associated with frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP), and are considered a major risk factor for this disease. As TMEM106B may be involved in other pathologies such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS), uncovering its cellular functions has become a priority. In this issue of The EMBO Journal, Schwenk et al (2014) combine loss-of-function experiments, live imaging and proteomics to unveil the physiological roles played by TMEM106B and its binding partner MAP6 in lysosomal function and transport." @default.
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- W2000901542 date "2014-02-04" @default.
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- W2000901542 title "TiME for TMEM106B" @default.
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- W2000901542 doi "https://doi.org/10.1002/embj.201387697" @default.
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