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- W2000902110 abstract "Exogenous angiotensin II (AII) administration produces a robust drinking response, even in water-satiated rats. All receptors are located in the hypothalamus and circumventricular organs (CVOs). Early postnatal administration of monosodium glutamate (MSG) produces hypothalamic/CVO damage. Therefore MSG might damage hypothalamic/CVO neurons important for producing the drinking response to AII. Few noninvasive procedures or tests exist to indicate the presence of a MSG lesion. Thus, the present study sought to determine whether altered water consumption after AII administration would signify the presence of a MSG lesion, as well as to demonstrate hypothalamic/CVO involvement in AII-induced drinking. Adult rats (dosed as neonates with MSG or saline) were given various doses of AII and the beta-adrenergic agonist isoproterenol. MSG-treated rats drank significantly less water after 100 ug/kg, sc AII than control rats. MSG-treated rats also had an unexpectedly high mortality after 100 ug/kg, sc isoproterenol. Thus, measurement of the drinking response may be a sensitive, noninvasive method for detecting neurotoxic damage to hypothalamic/CVO sites critical for the central action of AII." @default.
- W2000902110 created "2016-06-24" @default.
- W2000902110 creator A5072911449 @default.
- W2000902110 date "1995-07-01" @default.
- W2000902110 modified "2023-10-17" @default.
- W2000902110 title "Postnatal MSG treatment attenuates angiotensin II (AII) induced drinking in rats" @default.
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- W2000902110 doi "https://doi.org/10.1016/0031-9384(95)00031-d" @default.
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