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- W2000903896 abstract "In this study, the intracerebroventricular administration of 4-methylhistamine (3 and 10 micrograms/head), a histamine H2 receptor agonist, shortened the step-through latency in the retention trial using a step-through passive avoidance task in mice. This deteriorating effect of 4-methylhistamine (3 micrograms/head) was clearly antagonized by pretreatment with zolantidine (10 mg/kg, i.p.), a histamine H2 receptor antagonist, 20 min before an acquisition trial. Zolantidine alone at the dose tested had no effect. Thus, it is likely that activation of histamine H2 receptors has a deteriorating effect on avoidance learning in mice. The present results indicate the cognitive involvement by negative modulation of histamine H2 receptors in passive avoidance task in mice." @default.
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- W2000903896 date "1998-01-01" @default.
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- W2000903896 title "Cognitive involvement by negative modulation of histamine H2 receptors in passive avoidance task in mice" @default.
- W2000903896 doi "https://doi.org/10.1358/mf.1998.20.4.485684" @default.
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