FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000904952> ?p ?o ?g. }

• W2000904952 endingPage "1088" @default.
• W2000904952 startingPage "1081" @default.
• W2000904952 abstract "Covalently cross-linked proteins are among the major modifications caused by the advanced Maillard reaction. So far, the chemical nature of these aggregates is largely unknown. Investigations are reported on how the cross-linking unit 2-ammonio-6-[2-[(4-ammonio-5-oxido-5-oxopentyl)amino]-6,7-dihydrox y-4,5,6,7,8,8a-hexahydroimidazo[4,5-b]azepin-4-yl] hexanoate (7), designated as glucosepan, can be identified and quantified from D-glucose-bovine serum albumin (BSA) incubations. Independent synthesis and unequivocal structural characterization are given for glucosepan 7. A protocol was established for its determination by LC-MS with electrospray ionization (ESI). BSA and D-glucose were incubated at 37 degrees C, pH 7.4 for eight weeks and the time-dependent formation of 7 was observed. Since glucosepan 7 is unstable under acid proteolytic conditions, BSA was cleaved enzymatically. The maximum value obtained from a solution containing 50 g/L BSA and 100 mM D-glucose after eight weeks incubation time corresponds to an arginine derivatization rate of 1.38 +/- 0.07 mmol 7/mol Arg (equivalent to 31.7 +/- 1.6 mmol 7/mol BSA). From these results, it seems justified to expect 7 to play an important role in the cross-linking of proteins in vivo as well as in foodstuffs. The structural similarity of glucosepan 7 and pentosidine 1 made it obvious to also look for an eventual parallelism in the respective formation pathways." @default.
• W2000904952 created "2016-06-24" @default.
• W2000904952 creator A5053927539 @default.
• W2000904952 creator A5063387499 @default.
• W2000904952 date "1999-06-01" @default.
• W2000904952 modified "2023-10-14" @default.
• W2000904952 title "Cross-linking of proteins by maillard processes—characterization and detection of a lysine-arginine cross-link derived from d-glucose" @default.
• W2000904952 cites W1557253076 @default.
• W2000904952 cites W1757241200 @default.
• W2000904952 cites W1964649339 @default.
• W2000904952 cites W1968027668 @default.
• W2000904952 cites W1981369593 @default.
• W2000904952 cites W1985854958 @default.
• W2000904952 cites W1989559076 @default.
• W2000904952 cites W1993039489 @default.
• W2000904952 cites W1998514435 @default.
• W2000904952 cites W1999493479 @default.
• W2000904952 cites W2000896479 @default.
• W2000904952 cites W2001864263 @default.
• W2000904952 cites W2007844422 @default.
• W2000904952 cites W2010686055 @default.
• W2000904952 cites W2017214714 @default.
• W2000904952 cites W2025748287 @default.
• W2000904952 cites W2034854571 @default.
• W2000904952 cites W2067407043 @default.
• W2000904952 cites W2075422811 @default.
• W2000904952 cites W2077995076 @default.
• W2000904952 cites W2095352018 @default.
• W2000904952 cites W2117086217 @default.
• W2000904952 cites W2182421376 @default.
• W2000904952 cites W2315500707 @default.
• W2000904952 cites W2987634201 @default.
• W2000904952 cites W315995179 @default.
• W2000904952 cites W820854987 @default.
• W2000904952 doi "https://doi.org/10.1016/s0968-0896(99)00040-1" @default.
• W2000904952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10428377" @default.
• W2000904952 hasPublicationYear "1999" @default.
• W2000904952 type Work @default.
• W2000904952 sameAs 2000904952 @default.
• W2000904952 citedByCount "54" @default.
• W2000904952 countsByYear W20009049522012 @default.
• W2000904952 countsByYear W20009049522013 @default.
• W2000904952 countsByYear W20009049522015 @default.
• W2000904952 countsByYear W20009049522016 @default.
• W2000904952 countsByYear W20009049522017 @default.
• W2000904952 countsByYear W20009049522018 @default.
• W2000904952 countsByYear W20009049522019 @default.
• W2000904952 countsByYear W20009049522020 @default.
• W2000904952 countsByYear W20009049522021 @default.
• W2000904952 countsByYear W20009049522022 @default.
• W2000904952 countsByYear W20009049522023 @default.
• W2000904952 crossrefType "journal-article" @default.
• W2000904952 hasAuthorship W2000904952A5053927539 @default.
• W2000904952 hasAuthorship W2000904952A5063387499 @default.
• W2000904952 hasConcept C147990577 @default.
• W2000904952 hasConcept C162356407 @default.
• W2000904952 hasConcept C170493617 @default.
• W2000904952 hasConcept C178790620 @default.
• W2000904952 hasConcept C180577832 @default.
• W2000904952 hasConcept C185592680 @default.
• W2000904952 hasConcept C2776016237 @default.
• W2000904952 hasConcept C2776923573 @default.
• W2000904952 hasConcept C2777468819 @default.
• W2000904952 hasConcept C2780758796 @default.
• W2000904952 hasConcept C35378473 @default.
• W2000904952 hasConcept C40684141 @default.
• W2000904952 hasConcept C43617362 @default.
• W2000904952 hasConcept C515207424 @default.
• W2000904952 hasConcept C55493867 @default.
• W2000904952 hasConcept C71240020 @default.
• W2000904952 hasConcept C86807702 @default.
• W2000904952 hasConceptScore W2000904952C147990577 @default.
• W2000904952 hasConceptScore W2000904952C162356407 @default.
• W2000904952 hasConceptScore W2000904952C170493617 @default.
• W2000904952 hasConceptScore W2000904952C178790620 @default.
• W2000904952 hasConceptScore W2000904952C180577832 @default.
• W2000904952 hasConceptScore W2000904952C185592680 @default.
• W2000904952 hasConceptScore W2000904952C2776016237 @default.
• W2000904952 hasConceptScore W2000904952C2776923573 @default.
• W2000904952 hasConceptScore W2000904952C2777468819 @default.
• W2000904952 hasConceptScore W2000904952C2780758796 @default.
• W2000904952 hasConceptScore W2000904952C35378473 @default.
• W2000904952 hasConceptScore W2000904952C40684141 @default.
• W2000904952 hasConceptScore W2000904952C43617362 @default.
• W2000904952 hasConceptScore W2000904952C515207424 @default.
• W2000904952 hasConceptScore W2000904952C55493867 @default.
• W2000904952 hasConceptScore W2000904952C71240020 @default.
• W2000904952 hasConceptScore W2000904952C86807702 @default.
• W2000904952 hasIssue "6" @default.
• W2000904952 hasLocation W20009049521 @default.
• W2000904952 hasLocation W20009049522 @default.
• W2000904952 hasOpenAccess W2000904952 @default.
• W2000904952 hasPrimaryLocation W20009049521 @default.
• W2000904952 hasRelatedWork W2007375276 @default.
• W2000904952 hasRelatedWork W2025420631 @default.
• W2000904952 hasRelatedWork W2039842631 @default.
• W2000904952 hasRelatedWork W2068405110 @default.
• W2000904952 hasRelatedWork W2071464139 @default.

• next