FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000905327> ?p ?o ?g. }

• W2000905327 endingPage "24" @default.
• W2000905327 startingPage "16" @default.
• W2000905327 abstract "Okadaic acid (OA), a potent mouse skin tumor promoter and inhibitor of the protein phosphatases 1 and 2A, was investigated for its effects on the expression of tumor-associated early and secondary response genes in mouse keratinocytes. Adult mice were treated topically with 12.5 nmol of OA, and the steady-state levels of various gene transcripts in the skin were determined at different times after treatment. The nuclear protooncogenes c-fos and c-jun are referred to as early response genes because the classical tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces their expression to maximal levels within 2 h after treatment. OA induced the expression of c-fos 2–72 h after treatment, with two peaks at 6 and 48 h. The steady-state level of expression of c-jun was relatively high in untreated skin, and OA induced a slight increase in its expression from 12 to 48 h after treatment. Transin and plasminogen-activator (PA) urokinase, whose induced expression peaks at least 4 h after TPA treatment, are referred to as secondary response genes. OA induced their expression more slowly than TPA. In mouse papilloma cell line 308, OA induced higher and more sustained steady-state levels of c-jun and c-fos than an equimolar dose of TPA. Transin and PA-urokinase were induced to similar levels by TPA and OA in 308 cells; however, the induction of these genes by OA was slower than induction by TPA. The existence of different patterns of induced expression of early and secondary response genes by OA and TPA suggests that these tumor promoters affect gene expression in mouse keratinocytes through different pathways." @default.
• W2000905327 created "2016-06-24" @default.
• W2000905327 creator A5028634203 @default.
• W2000905327 creator A5052752260 @default.
• W2000905327 creator A5055376182 @default.
• W2000905327 date "1992-01-01" @default.
• W2000905327 modified "2023-09-30" @default.
• W2000905327 title "Okadaic acid induces the expression of both early and secondary response genes in mouse keratinocytes" @default.
• W2000905327 cites W1527577334 @default.
• W2000905327 cites W1564906738 @default.
• W2000905327 cites W1749352888 @default.
• W2000905327 cites W1816187765 @default.
• W2000905327 cites W1826186819 @default.
• W2000905327 cites W1831164682 @default.
• W2000905327 cites W1883847229 @default.
• W2000905327 cites W1908718505 @default.
• W2000905327 cites W1916260177 @default.
• W2000905327 cites W1954580706 @default.
• W2000905327 cites W1966645093 @default.
• W2000905327 cites W1967004332 @default.
• W2000905327 cites W1967653587 @default.
• W2000905327 cites W1968199586 @default.
• W2000905327 cites W1973135307 @default.
• W2000905327 cites W1980536676 @default.
• W2000905327 cites W1983606213 @default.
• W2000905327 cites W1990205754 @default.
• W2000905327 cites W1996709883 @default.
• W2000905327 cites W1997261857 @default.
• W2000905327 cites W2001411250 @default.
• W2000905327 cites W2001692359 @default.
• W2000905327 cites W2005150284 @default.
• W2000905327 cites W2009884429 @default.
• W2000905327 cites W2011374830 @default.
• W2000905327 cites W2014484852 @default.
• W2000905327 cites W2015886184 @default.
• W2000905327 cites W2017030322 @default.
• W2000905327 cites W2022676856 @default.
• W2000905327 cites W2022729618 @default.
• W2000905327 cites W2028642327 @default.
• W2000905327 cites W2029209336 @default.
• W2000905327 cites W2031415417 @default.
• W2000905327 cites W2039333302 @default.
• W2000905327 cites W2042917468 @default.
• W2000905327 cites W2045457726 @default.
• W2000905327 cites W2051922709 @default.
• W2000905327 cites W2052537645 @default.
• W2000905327 cites W2058744360 @default.
• W2000905327 cites W2059796872 @default.
• W2000905327 cites W2061236267 @default.
• W2000905327 cites W2063572593 @default.
• W2000905327 cites W2070849933 @default.
• W2000905327 cites W2070965152 @default.
• W2000905327 cites W2073784653 @default.
• W2000905327 cites W2077088537 @default.
• W2000905327 cites W2077904476 @default.
• W2000905327 cites W2078146089 @default.
• W2000905327 cites W2080184511 @default.
• W2000905327 cites W2080216367 @default.
• W2000905327 cites W2081135713 @default.
• W2000905327 cites W2085712277 @default.
• W2000905327 cites W2087761237 @default.
• W2000905327 cites W2088485389 @default.
• W2000905327 cites W2089003647 @default.
• W2000905327 cites W2094872845 @default.
• W2000905327 cites W2096690447 @default.
• W2000905327 cites W2098199930 @default.
• W2000905327 cites W2104014673 @default.
• W2000905327 cites W2129388998 @default.
• W2000905327 cites W2135339319 @default.
• W2000905327 cites W2167604659 @default.
• W2000905327 cites W222863809 @default.
• W2000905327 cites W23122061 @default.
• W2000905327 cites W2314795980 @default.
• W2000905327 cites W2341373405 @default.
• W2000905327 cites W2421037982 @default.
• W2000905327 cites W311570066 @default.
• W2000905327 cites W4232159674 @default.
• W2000905327 cites W4237822095 @default.
• W2000905327 doi "https://doi.org/10.1002/mc.2940050106" @default.
• W2000905327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1543537" @default.
• W2000905327 hasPublicationYear "1992" @default.
• W2000905327 type Work @default.
• W2000905327 sameAs 2000905327 @default.
• W2000905327 citedByCount "40" @default.
• W2000905327 countsByYear W20009053272012 @default.
• W2000905327 countsByYear W20009053272014 @default.
• W2000905327 countsByYear W20009053272017 @default.
• W2000905327 crossrefType "journal-article" @default.
• W2000905327 hasAuthorship W2000905327A5028634203 @default.
• W2000905327 hasAuthorship W2000905327A5052752260 @default.
• W2000905327 hasAuthorship W2000905327A5055376182 @default.
• W2000905327 hasConcept C104317684 @default.
• W2000905327 hasConcept C134018914 @default.
• W2000905327 hasConcept C150194340 @default.
• W2000905327 hasConcept C153911025 @default.
• W2000905327 hasConcept C178666793 @default.
• W2000905327 hasConcept C181199279 @default.
• W2000905327 hasConcept C195794163 @default.

• next