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• W2000906360 startingPage "147" @default.
• W2000906360 abstract "Existing therapies for allergic asthma are far from perfect: the global prevalence of disease increases despite them and they are poorly effective in dealing with the exacerbations that account for hospitalization and asthma deaths. Commercially, there are pressures on these existing medicines too – a growing threat from generics and reluctance by payers to reimburse for increasingly marginal improvements in medicines with precedented mechanisms. Experience shows that attempts to devise selective small-molecule interventions directed at the myriad of downstream effector pathways has not been a fertile ground for the development of effective new medicines. An alternative strategy, exploiting breakthroughs in understanding the molecular basis of allergenicity and the key role of innate immune mechanisms in asthma, is to direct new approaches to the disease triggers themselves: allergens. This raises interesting possibilities for anti-Lipinski drug design (extracellular nonhuman targets, inhaled delivery) and creates unprecedented pharmacological opportunities in the therapeutic area." @default.
• W2000906360 created "2016-06-24" @default.
• W2000906360 creator A5017881708 @default.
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• W2000906360 creator A5059475751 @default.
• W2000906360 creator A5066499315 @default.
• W2000906360 date "2013-02-01" @default.
• W2000906360 modified "2023-09-26" @default.
• W2000906360 title "Nonhuman targets in allergic lung conditions" @default.
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