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• W2000906752 abstract "The four core genotypes (FCG) mouse model has emerged as a major model testing if sex differences in phenotypes are caused by sex chromosome complement (XX vs. XY) or gonadal hormones or both. The model involves deletion of the testis-determining gene Sry from the Y chromosome and insertion of an Sry transgene onto an autosome. It produces XX and XY mice with testes, and XX and XY mice with ovaries, so that XX and XY mice with the same type of gonad can be compared to assess phenotypic effects of sex chromosome complement in cells and tissues.We used PCR to amplify the Sry transgene and adjacent genomic sequences, to resolve the location of the Sry transgene to chromosome 3 and confirmed this location by fluorescence in situ hybridization (FISH) of the Sry construct to metaphase chromosomes. Using quantitative PCR, we estimate that 12-14 copies of the transgene were inserted. The anogenital distance (AGD) of FCG pups at 27-29 days after birth was not different in XX vs. XY males, or XX vs. XY females, suggesting that differences between XX and XY mice with the same type of gonad are not caused by difference in prenatal androgen levels.The Sry transgene in FCG mice is present in multiple copies at one locus on chromosome 3, which does not interrupt known genes. XX and XY mice with the same type of gonad do not show evidence of different androgen levels prenatally." @default.
• W2000906752 created "2016-06-24" @default.
• W2000906752 creator A5015295070 @default.
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• W2000906752 date "2015-03-07" @default.
• W2000906752 modified "2023-10-15" @default.
• W2000906752 title "Four Core Genotypes mouse model: localization of the Sry transgene and bioassay for testicular hormone levels" @default.
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• W2000906752 doi "https://doi.org/10.1186/s13104-015-0986-2" @default.
• W2000906752 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4354741" @default.
• W2000906752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25870930" @default.
• W2000906752 hasPublicationYear "2015" @default.
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• W2000906752 citedByCount "65" @default.

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